What's New
2025-02-01 - present: Repository timeouts. Due to a networking problem on our service provider, the Digital Research Alliance of Canada, we are seeing intermittent repository query time outs. This will appear in the Gateway as error messages stating the repositories did not respond and will result in incomplete and inconsistent results across queries. Please be wary of statistics and results that include error messages involving repository problems. We apologize for the inconvenience, we are working on a solution.
A science gateway that enables the discovery, analysis, and download of AIRR-seq data (antibody/B-cell and T-cell receptor repertoires) from the 10 remote repositories in the AIRR Data Commons (ADC). Search for disease data (e.g. cancer, autoimmunity, infections) and healthy controls.
5.2 billion annotated sequences (bulk/single-cell) from 10350 repertoires, 95 studies, 10 repositories
10 remote repositories, 79 research labs, 95 studies
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AIRR COVID-19
765.8 million sequences
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Lab:
Adaptive Biotechnologies
543.4 million sequences
- Study: Nolan et al., COVID-19-Adaptive: A large-scale database of T-cel‥ 111.7 million sequences
- Study: Nolan et al., COVID-19-BWNW: A large-scale database of T-cell re‥ 33.2 million sequences
- Study: Nolan et al., COVID-19-DLS: A large-scale database of T-cell rec‥ 155.4 million sequences
- Study: Nolan et al., COVID-19-HUniv12Oct: A large-scale database of T-c‥ 84.2 million sequences
- Study: Nolan et al., COVID-19-IRST/AUSL: A large-scale database of T-ce‥ 29 million sequences
- Study: Nolan et al., COVID-19-ISB: A large-scale database of T-cell rec‥ 74.3 million sequences
- Study: Nolan et al., COVID-19-NIH/NIAID: A large-scale database of T-ce‥ 55.4 million sequences
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Lab:
Alchemab Therapeutics Ltd
3.7 million sequences
- Study: Galson et al., Deep sequencing of B cell receptor repertoires fr‥ 3.7 million sequences
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Lab:
Binder Lab, Department of Internal Medicine IV, Oncology/Hematol‥
15.1 million sequences
- Study: Schultheiß et al., Next Generation Sequencing of T and B cell re‥ 15.1 million sequences
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Lab:
Boyd Lab, Department of Pathology, Stanford University
8.9 million sequences
- Study: Nielsen et al., B cell clonal expansion and convergent antibody‥ 8.9 million sequences
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Lab:
Cancer Research Institute, Seoul National University College of‥
3.4 million sequences
- Study: Kim et al., Stereotypic Neutralizing VH Clonotypes Against SARS-‥ 3.4 million sequences
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Lab:
Efimov Lab, National Research Centre for Hematology, Moscow, Rus‥
7.7 million sequences
- Study: Shomuradova et al., SARS-CoV-2 epitopes are recognized by a publ‥ 7.7 million sequences
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Lab:
Ellebedy Lab, Department of Pathology and Immunology, Washington‥
54 thousand sequences
- Study: Alsoussi et al., A Potently Neutralizing Antibody Protects Mice‥ 13 thousand sequences
- Study: Turner et al., SARS-CoV-2 mRNA vaccines induce persistent human‥ 41 thousand sequences
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Lab:
Ellebedy Lab, Washington University School of Medicine
406 thousand sequences
- Study: Schmitz et al., A vaccine-induced public antibody protects again‥ 406 thousand sequences
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Lab:
Institute for Hepatology, National Clinical Research Center for‥
66.9 million sequences
- Study: Liao et al., Single-cell landscape of bronchoalveolar immune cel‥ 66.9 million sequences
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Lab:
Mora Lab, Laboratoire de physique de l’École normale supérieure‥
87.1 million sequences
- Study: Minervina et al., Longitudinal high-throughput TCR repertoire pr‥ 87.1 million sequences
-
Lab:
National Center for Liver Cancer, Second Military Medical Univer‥
104 thousand sequences
- Study: Wen et al., Immune cell profiling of COVID-19 patients in the re‥ 104 thousand sequences
-
Lab:
Pardi Lab, Department of Medicine, University of Pennsylvania
3 million sequences
- Study: Alameh et al., Lipid nanoparticles enhance the efficacy of mRNA‥ 3 million sequences
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Lab:
Perelman School of Medicine, University of Pennsylvania
11.9 million sequences
- Study: Kuri-Cervantes et al., Comprehensive mapping of immune perturbat‥ 11.9 million sequences
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Lab:
Reynaud Lab, Institut Necker Enfants Malades (INEM), INSERM
104 thousand sequences
- Study: Sokal et al., Maturation and persistence of the anti-SARS-CoV-2‥ 104 thousand sequences
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Lab:
Thomas Lab, Department of Immunology, St. Jude Children’s Resear‥
23 thousand sequences
- Study: Minervina et al., SARS-CoV-2 antigen exposure history shapes phe‥ 23 thousand sequences
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Lab:
Wherry Lab, Perelman School of Medicine, University of Pennsylva‥
13.5 million sequences
- Study: Goel et al., Distinct antibody and memory B cell responses in SA‥ 4.4 million sequences
- Study: Goel et al., mRNA Vaccination Induces Durable Immune Memory to S‥ 9.1 million sequences
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Lab:
Adaptive Biotechnologies
543.4 million sequences
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Greiff Lab
9.9 million sequences
-
Lab:
Alchemab Therapeutics Ltd, London, United Kingdom
4.8 million sequences
- Study: Lê Quý, et al. Benchmarking and integrating human B-cell recepto‥ 9.9 million sequences
-
Lab:
Computational and System Immunology lab, Department of Immunolog‥
5 million sequences
- Study: Lê Quý, et al. Benchmarking and integrating human B-cell recepto‥ 9.9 million sequences
-
Lab:
Alchemab Therapeutics Ltd, London, United Kingdom
4.8 million sequences
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HPAP
1.1 million sequences
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Lab:
Luning Prak Lab, Perelman School of Medicine, University of Penn‥
1.1 million sequences
- Study: Human Pancreas Analysis Program T1D bulk TRB data 1.1 million sequences
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Lab:
Luning Prak Lab, Perelman School of Medicine, University of Penn‥
1.1 million sequences
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iReceptor Public Archive
1.8 billion sequences
-
Lab:
Bagnara Lab, Department of Experimental Medicine, University of‥
38.8 million sequences
- Study: Vergani et al., Novel Method for High-Throughput Full-Length IGH‥ 38.8 million sequences
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Lab:
Bo Zhu Lab, Institute of Cancer, Xinqiao Hospital, Third Militar‥
9 million sequences
- Study: Jia et al., Local mutational diversity drives intratumoral immun‥ 9 million sequences
-
Lab:
Chang Lab, Center for Personal Dynamic Regulomes, Stanford Unive‥
118 thousand sequences
- Study: Yost et al., Clonal replacement of tumor-specific T cells follow‥ 118 thousand sequences
-
Lab:
Chudakov Lab, Shemyakin-Ovchinnikov Institute of Bioorganic Chem‥
452.3 million sequences
- Study: Zvyagin et al., Tracking T-cell immune reconstruction after TCR/‥ 452.3 million sequences
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Lab:
Collins Lab, School of Biotechnology and Biomolecular Sciences,‥
1.1 million sequences
- Study: Collins et al., The Mouse Antibody Heavy Chain Repertoire Is Ger‥ 1.1 million sequences
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Lab:
Department of Immunology and Microbiology, University of Colorad‥
49.9 million sequences
- Study: Munson et al., Identification of shared TCR sequences from T cel‥ 49.9 million sequences
-
Lab:
Department of Neurological Surgery, Columbia University Medical‥
144.9 million sequences
- Study: Sims et al., Diversity and divergence of the glioma-infiltrating‥ 144.9 million sequences
-
Lab:
Fire Lab, Department of Pathology, Stanford University
1 million sequences
- Study: Boyd et al., Measurement and Clinical Monitoring of Human Lympho‥ 1 million sequences
-
Lab:
Institute of Molecular and Genomic Medicine, National Health Res‥
61.1 million sequences
- Study: Chang et al., Network Signatures of IgG Immune Repertoires in He‥ 61.1 million sequences
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Lab:
Kellam Lab, Wellcome Trust Sanger Institute
1 million sequences
- Study: Bashford-Rogers et al., Network properties derived from deep seq‥ 1 million sequences
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Lab:
Key Laboratory of Carcinogenesis and Translational Research (Min‥
82.4 million sequences
- Study: Chen et al., T cell Beta chain repertoire analysis reveals intra‥ 82.4 million sequences
-
Lab:
Lebedev Lab, Department of Genomics of Adaptive Immunity, Shemya‥
426.4 million sequences
- Study: Pogorelyy et al., Precise tracking of vaccine-responding T cell‥ 426.4 million sequences
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Lab:
Martinez-Barnetche Lab, Departamento de Inmunología; Centro de I‥
713 thousand sequences
- Study: Valdés-Alemán et al., Hybridization-based antibody cDNA recovery‥ 713 thousand sequences
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Lab:
Mehr Lab, The Mina and Everard Goodman Faculty of Life Sciences,‥
27 thousand sequences
- Study: Michaeli et al., Immunoglobulin gene repertoire diversification‥ 27 thousand sequences
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Lab:
National Cancer Center/Cancer Hospital, Chinese Academy of Medic‥
29.2 million sequences
- Study: Feng et al., Heterogeneity of tumor-infiltrating lymphocytes asc‥ 29.2 million sequences
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Lab:
Sanz Lab, Department of Medicine, Division of Rheumatology, Emor‥
27.9 million sequences
- Study: Tipton et al., Diversity, cellular origin and autoreactivity of‥ 27.9 million sequences
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Lab:
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian‥
55 million sequences
- Study: Putintseva et al., Mother and child T cell receptor repertoires:‥ 55 million sequences
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Lab:
Sollid Lab, Centre for Immune Regulation and Department of Immun‥
32.6 million sequences
- Study: Snir et al., Stereotyped antibody responses target posttranslati‥ 32.6 million sequences
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Lab:
State Key Laboratory of Molecular Oncology, Department of Etiolo‥
95.2 million sequences
- Study: Shi et al., Multi-omics study revealing the complexity and spati‥ 95.2 million sequences
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Lab:
Vaccine Research Center, National Institutes of Health
3.8 million sequences
- Study: Zhou et al., Multi-donor Analysis Reveal Structural Elements, Ge‥ 3.8 million sequences
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Lab:
Vaccine Research Center, National Institutes of Health Intramura‥
3.6 million sequences
- Study: Zhu et al., Mining the antibodyome for HIV-1 neutralizing antibo‥ 3.6 million sequences
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Lab:
von Buedingen Lab, Department of Neurology, University of Califo‥
1.2 million sequences
- Study: Palanichamy et al., Immunoglobulin class-switched B cells provid‥ 1.2 million sequences
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Lab:
Xiao Liu Lab, BGI-Shenzhen
312.1 million sequences
- Study: Wang et al., The Different T-cell Receptor Repertoires in Breast‥ 312.1 million sequences
-
Lab:
Bagnara Lab, Department of Experimental Medicine, University of‥
38.8 million sequences
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Roche
17.2 million sequences
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Lab:
Hayday Lab, Peter Gorer Department of Immunobiology, King's Coll‥
17.2 million sequences
- Study: Global patterns of antigen receptor repertoire disruption across‥ 17.2 million sequences
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Lab:
Hayday Lab, Peter Gorer Department of Immunobiology, King's Coll‥
17.2 million sequences
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sciReptor
20 thousand sequences
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Lab:
Div. B Cell Immunology, German Cancer Research Center
3 thousand sequences
- Study: Lorenzo et al., ALDH4A1 is an atherosclerosis auto-antigen targe‥ 3 thousand sequences
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Lab:
MPRG Molucular Immunology, MPI Infection Biology
17 thousand sequences
- Study: Busse et al., Single-cell based high-throughput sequencing of fu‥ 532 sequences
- Study: omega 16 thousand sequences
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Lab:
Div. B Cell Immunology, German Cancer Research Center
3 thousand sequences
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T1D
117.6 million sequences
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Lab:
Barbara Davis Center for Diabetes
62.1 million sequences
- Study: Anderson et al., Human islet T cells are highly reactive to prep‥ 6 thousand sequences
- Study: Mitchell et al., Temporal development of T cell receptor reperto‥ 62.1 million sequences
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Lab:
Benaroya Research Institute
9.6 million sequences
- Study: Culina et al., Islet-reactive CD8+ T cell frequencies in the pan‥ 9.6 million sequences
-
Lab:
Immunobiology Dpt. King's College London
34.4 million sequences
- Study: Eugster et al., Physiological and pathogenic T cell autoreactivi‥ 688 sequences
- Study: Gomez-Tourino et al., T cell receptor β-chains display abnormal‥ 34.4 million sequences
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Lab:
University of Florida Diabetes Institute
11 million sequences
- Study: Seay et al., Tissue distribution and clonal diversity of the T a‥ 11 million sequences
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Lab:
University of Massachusetts Chan Medical School
195 thousand sequences
- Study: Kent et al., Islet-derived, in vitro polyclonally expanded T cel‥ 195 thousand sequences
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Lab:
Barbara Davis Center for Diabetes
62.1 million sequences
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University of Münster
3.6 million sequences
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Lab:
Institut für Translationale Neurologie
3.6 million sequences
- Study: CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated b‥ 3.6 million sequences
-
Lab:
Institut für Translationale Neurologie
3.6 million sequences
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VDJbase
212 thousand sequences
-
Lab:
Freund Lab, Faculty of Medicine, Tel Aviv University
212 thousand sequences
- Study: Mor et al., Multi-clonal SARS-CoV-2 neutralization by antibodies‥ 212 thousand sequences
-
Lab:
Freund Lab, Faculty of Medicine, Tel Aviv University
212 thousand sequences
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VDJServer
2.5 billion sequences
-
Lab:
Adaptive Biotechnologies
308.2 million sequences
- Study: A large-scale database of T-cell receptor beta (TCRb) sequences‥ 308.2 million sequences
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Lab:
Ali H. Ellebedy
12 thousand sequences
- Study: A Potently Neutralizing Antibody Protects Mice against SARS-CoV-‥ 12 thousand sequences
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Lab:
Anne Eugster
130.8 million sequences
- Study: T cell receptor repertoires after adoptive transfer of expanded‥ 130.8 million sequences
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Lab:
Armita Nourmohammad and Chris Ka Pun Mok
18.9 million sequences
- Study: Dynamics of B-cell repertoires and emergence of cross-reactive r‥ 18.9 million sequences
-
Lab:
Dana Pe’er
106 thousand sequences
- Study: Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor‥ 106 thousand sequences
-
Lab:
Dennis R. Burton
405.4 million sequences
- Study: Uniqueness, commonality and exceptional diversity in the baselin‥ 405.4 million sequences
-
Lab:
George Georgiou
101.1 million sequences
- Study: In-depth determination and analysis of the human paired heavy- a‥ 45.7 million sequences
- Study: Large-scale sequence and structural comparisons of human naive a‥ 55.4 million sequences
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Lab:
Harlan Robins
245.2 million sequences
- Study: A public database of memory and naive B-cell receptor sequences 46.6 million sequences
- Study: Dynamics of the Cytotoxic T Cell Response to a Model of Acute Vi‥ 6.9 million sequences
- Study: Immunosequencing identifies signatures of cytomegalovirus exposu‥ 191.6 million sequences
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Lab:
Ignacio Sanz
15 thousand sequences
- Study: Extrafollicular B cell responses correlate with neutralizing ant‥ 15 thousand sequences
-
Lab:
Ivelin S. Georgiev
14 thousand sequences
- Study: High-Throughput Mapping of B Cell Receptor Sequences to Antigen‥ 14 thousand sequences
-
Lab:
James E. Crowe Jr
1.1 billion sequences
- Study: High Frequency of Shared Clonotypes in Human T Cell Receptor Rep‥ 1.1 billion sequences
-
Lab:
Jia Zhu
37 thousand sequences
- Study: Distinct populations of antigen-specific tissue-resident CD8+ T‥ 37 thousand sequences
-
Lab:
Jianxin Shi and Mahboobeh Safaeian
3.4 million sequences
- Study: T cell receptor repertoire among women who cleared and failed to‥ 3.4 million sequences
-
Lab:
Jörg J Goronzy
56.9 million sequences
- Study: Determinants governing T cell receptor α/β-chain pairing in repe‥ 56.9 million sequences
-
Lab:
Lawrence Shapiro
6.6 million sequences
- Study: Maturation and Diversity of the VRC01-Antibody Lineage over 15 Y‥ 6.6 million sequences
-
Lab:
Lindsay Cowell
94 thousand sequences
- Study: Biophysicochemical Motifs in T cell Receptor Sequences as a Pote‥ 94 thousand sequences
-
Lab:
Lindsay G. Cowell
236 thousand sequences
- Study: T cell Receptor Repertoires Acquired via Routine Pap Testing May‥ 236 thousand sequences
-
Lab:
Lisong Shen
87 thousand sequences
- Study: Immune suppressive landscape in the human esophageal squamous ce‥ 87 thousand sequences
-
Lab:
Luis Graca
6.3 million sequences
- Study: T follicular helper and T follicular regulatory cells have diffe‥ 6.3 million sequences
-
Lab:
Mark M. Davis
1.7 million sequences
- Study: Individual heritable differences result in unique cell lymphocyt‥ 1.7 million sequences
-
Lab:
Michael R. Wilson
438 thousand sequences
- Study: A pathogenic and clonally expanded B cell transcriptome in activ‥ 438 thousand sequences
-
Lab:
Pandurangan Vijayanand
367 thousand sequences
- Study: Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4 +‥ 367 thousand sequences
-
Lab:
Rafi Ahmed
183 thousand sequences
- Study: Functional HPV-specific PD-1+ stem-like CD8 T cells in head and‥ 183 thousand sequences
-
Lab:
Raquibul Hannan
782 thousand sequences
- Study: Outcome and Immune Correlates of a Phase II Trial of High-Dose I‥ 782 thousand sequences
-
Lab:
Sai T. Reddy
125.4 million sequences
- Study: Antibody repertoire RNA-seq throughout key stages of mouse B-cel‥ 125.4 million sequences
-
Lab:
Steven H. Kleinstein
17.3 million sequences
- Study: A Model of Somatic Hypermutation Targeting in Mice Based on High‥ 1.1 million sequences
- Study: B cells populating the multiple sclerosis brain mature in the dr‥ 6.7 million sequences
- Study: Hierarchical Clustering Can Identify B Cell Clones With High Con‥ 9.4 million sequences
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Lab:
UNKNOWN
- Study: Low avidity T cell responses to SARS-CoV-2 in unexposed individu‥ 125 thousand sequences
-
Lab:
Zheng Zhang
11 thousand sequences
- Study: Single-cell landscape of bronchoalveolar immune cells in patient‥ 11 thousand sequences
-
Lab:
Adaptive Biotechnologies
308.2 million sequences
See all AIRR Data Commons repositories queried by the iReceptor Gateway
67 thousand clones aggregated from 64 repertoires, 2 studies, 2 repositories
10 remote repositories, 79 research labs, 95 studies
-
AIRR COVID-19
37 thousand clones
-
Lab:
National Center for Liver Cancer, Second Military Medical Univer‥
37 thousand clones
- Study: Wen et al., Immune cell profiling of COVID-19 patients in the re‥ 37 thousand clones
-
Lab:
National Center for Liver Cancer, Second Military Medical Univer‥
37 thousand clones
-
iReceptor Public Archive
30 thousand clones
-
Lab:
Chang Lab, Center for Personal Dynamic Regulomes, Stanford Unive‥
30 thousand clones
- Study: Yost et al., Clonal replacement of tumor-specific T cells follow‥ 30 thousand clones
-
Lab:
Chang Lab, Center for Personal Dynamic Regulomes, Stanford Unive‥
30 thousand clones
530 thousand sorted, single B/T cells with paired receptors, gene expression, and cell phenotype from 175 repertoires, 5 studies, 4 repositories
10 remote repositories, 79 research labs, 95 studies
-
AIRR COVID-19
67 thousand cells
-
Lab:
National Center for Liver Cancer, Second Military Medical Univer‥
54 thousand cells
- Study: Wen et al., Immune cell profiling of COVID-19 patients in the re‥ 54 thousand cells
-
Lab:
Thomas Lab, Department of Immunology, St. Jude Children’s Resear‥
12 thousand cells
- Study: Minervina et al., SARS-CoV-2 antigen exposure history shapes phe‥ 12 thousand cells
-
Lab:
National Center for Liver Cancer, Second Military Medical Univer‥
54 thousand cells
-
Greiff Lab
396 thousand cells
-
Lab:
Alchemab Therapeutics Ltd, London, United Kingdom
122 thousand cells
- Study: Lê Quý, et al. Benchmarking and integrating human B-cell recepto‥ 396 thousand cells
-
Lab:
Computational and System Immunology lab, Department of Immunolog‥
274 thousand cells
- Study: Lê Quý, et al. Benchmarking and integrating human B-cell recepto‥ 396 thousand cells
-
Lab:
Alchemab Therapeutics Ltd, London, United Kingdom
122 thousand cells
-
iReceptor Public Archive
66 thousand cells
-
Lab:
Chang Lab, Center for Personal Dynamic Regulomes, Stanford Unive‥
66 thousand cells
- Study: Yost et al., Clonal replacement of tumor-specific T cells follow‥ 66 thousand cells
-
Lab:
Chang Lab, Center for Personal Dynamic Regulomes, Stanford Unive‥
66 thousand cells
-
T1D
482 cells
-
Lab:
Immunobiology Dpt. King's College London
482 cells
- Study: Eugster et al., Physiological and pathogenic T cell autoreactivi‥ 482 cells
-
Lab:
Immunobiology Dpt. King's College London
482 cells