Nov 17, 2024
2024-10-28: Eighth T1D AIRR-seq study is now available in the AIRR Data Commons using the iReceptor Gateway. Paired chain data from Eugster et al., "Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes" now available.
News Flash - new Analysis Apps. We are pleased to announce the availability of two new Analysis Apps available on the iReceptor Gateway. TCRMatch and a locally developed CDR3 Motif Search.
Nov 06, 2024
2024-11-07 - 2024-11-08 - Analysis Apps not available. Our compute provider has an outage and analysis Apps will not be available during this time.
2024-10-28: Eighth T1D AIRR-seq study is now available in the AIRR Data Commons using the iReceptor Gateway. Paired chain data from Eugster et al., "Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes" now available.
News Flash - new Analysis Apps. We are pleased to announce the availability of two new Analysis Apps available on the iReceptor Gateway. TCRMatch and a locally developed CDR3 Motif Search.
Nov 06, 2024
2024-10-28: Eighth T1D AIRR-seq study is now available in the AIRR Data Commons using the iReceptor Gateway. Paired chain data from Eugster et al., "Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes" now available.
News Flash - new Analysis Apps. We are pleased to announce the availability of two new Analysis Apps available on the iReceptor Gateway. TCRMatch and a locally developed CDR3 Motif Search.
Oct 31, 2024
VDJServer unavailable from 2024-11-04, 17:27 to 2024-11-05, 11:30 Pacific
2024-10-28: Eighth T1D AIRR-seq study is now available in the AIRR Data Commons using the iReceptor Gateway. Paired chain data from Eugster et al., "Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes" now available.
News Flash - new Analysis Apps. We are pleased to announce the availability of two new Analysis Apps available on the iReceptor Gateway. TCRMatch and a locally developed CDR3 Motif Search.
Oct 19, 2024
2024-10-19: News Flash - new Analysis Apps. We are pleased to announce the availability of two new Analysis Apps available on the iReceptor Gateway. TCRMatch can be used to predict epitope specificity on any repertoire that contains TCR beta chains and the iReceptor team has created a CDR3 Motif Search, using single character AA regular expressions.
2024-10-11: Due to unreliable file system performance on our compute provider, the Digital Research Alliance of Canada, iReceptor Gateway Analysis Jobs may either fail or run slowly. If a job fails, please resubmit, as the problems are intermittent. We apologize for any inconvenience, please email support at ireceptor dot org if you have questions.
Oct 16, 2024
2024-10-11 to 2024-10-16: Due to unreliable file system performance on our compute provider, the Digital Research Alliance of Canada, iReceptor Gateway Analysis Jobs were temporarily disabled. Jobs are again enabled, but performance of the compute system is still degraded so it is possible that jobs will either fail or run quite slowly. We apologize for any inconvenience, please email support at ireceptor dot org if you have questions.
2024-07-17: Seventh T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 198K annotated T-cell receptors from Sally Kent et al. "Islet-derived, in vitro polyclonally expanded T cell Sequencing" from nPOD samples by the Kent Lab at the UMass Chan Diabetes Center of Excellence.
Oct 11, 2024
2024-10-11: Due to unreliable file system performance on our compute provider, the Digital Research Alliance of Canada, iReceptor Gateway Analysis Jobs have been temporarily disabled. We apologize for the inconvenience, we are waiting on our service provider to provide more information and will update this message when we find out more details.
2024-07-17: Seventh T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 198K annotated T-cell receptors from Sally Kent et al. "Islet-derived, in vitro polyclonally expanded T cell Sequencing" from nPOD samples by the Kent Lab at the UMass Chan Diabetes Center of Excellence.
Oct 08, 2024
2024-10-08: We are experiencing unreliable file system performance issues on our compute provider, the Digital Research Alliance of Canada. It is possible that some Analysis Jobs will fail. Please resubmit failed jobs and if the problem persists email support at ireceptor.org. We apologize of the inconvenience, we are waiting on our service provider to provide more information and will update this message when we find out more information.
2024-07-17: Seventh T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 198K annotated T-cell receptors from Sally Kent et al. "Islet-derived, in vitro polyclonally expanded T cell Sequencing" from nPOD samples by the Kent Lab at the UMass Chan Diabetes Center of Excellence.
Sep 25, 2024
2024-07-17: Seventh T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 198K annotated T-cell receptors from Sally Kent et al. "Islet-derived, in vitro polyclonally expanded T cell Sequencing" from nPOD samples by the Kent Lab at the UMass Chan Diabetes Center of Excellence.
2024-09-23 22:00 - 2024-09-25 17:30 UTC: COVID-19 repository covid19-2.ireceptor.org was down for maintenance.
Sep 23, 2024
2024-09-23 22:00 UTC: One of the COVID-19 repositories (covid19-2.ireceptor.org) is down for maintenance, it will be back shortly.
Jul 17, 2024
2024-07-17: Seventh T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 198K annotated T-cell receptors from Sally Kent et al. "Islet-derived, in vitro polyclonally expanded T cell Sequencing" from nPOD samples by the Kent Lab at the UMass Chan Diabetes Center of Excellence.
Jul 09, 2024
2024-06-18: Sixth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 4.3 Million annotated T-cell receptors from Culina et al "Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors" are now available
2024-07-07 to 2024-07-09: Due to problems on our service provider, the IPA1 repository was down and not available for queries. It is now back in service.
Jul 08, 2024
2024-07-07: IPA1 down - Due to problems on our service provider, the IPA1 repository is down and is disabled on the iReceptor Gateway.
2024-06-18: Sixth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 4.3 Million annotated T-cell receptors from Culina et al "Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors" are now available
Jul 04, 2024
2024-06-18: Sixth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 4.3 Million annotated T-cell receptors from Culina et al "Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors" are now available
2024-06-14 to 2024-07-04: The VDJBase repository was down and disabled on the iReceptor Gateway. It is now back on line.
2024-06-30 to 2024-07-04: IPA1 repository was down and was disabled on the iReceptor Gateway. It is now back on line
Jul 01, 2024
2024-06-14: The VDJBase repository is currently down and is disabled on the iReceptor Gateway.
2024-06-30: IPA1 repository is currently down and is disabled on the iReceptor Gateway.
2024-06-18: Sixth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 4.3 Million annotated T-cell receptors from Culina et al "Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors" are now available
Jun 18, 2024
2024-06-18: Sixth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 4.3 Million annotated T-cell receptors from Culina et al "Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors" are now available
Jun 14, 2024
2024-06-14: The VDJBase repository is currently down and it has been disabled on the iReceptor Gateway. Any searches will not include the data from this repository. Please check here of updates.
Jun 10, 2024
2024-06-04 to 2024-06-10: Analysis jobs were unavailable because the compute system used by iReceptor Jobs was down for maintenance. All services are now up and running.
Jun 04, 2024
2024-06-04: Analysis jobs unavailable. The compute system used by iReceptor Jobs is down for maintenance, as our service provider is updating the network and OS on the compute cluster We expect the system to back on line on 2024-06-08
May 08, 2024
2024-02-07: Fifth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 32 Million annotated T-cell receptors from Gomez-Tourino et al "T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes" is now available
Note: VDJServer downloads are once again working.
May 08, 2024
2024-02-07: Fifth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 32 Million annotated T-cell receptors from Gomez-Tourino et al "T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes" is now available
Note: VDJServer downloads are currently not working, if you download data from VDJServer you will get an error message. The VDJServer team is working on the problem.
Mar 28, 2024
2024-02-07: Fifth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 32 Million annotated T-cell receptors from Gomez-Tourino et al "T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes" is now available
Mar 23, 2024
Service outage, 2024-03-21 - 2024--03-23: During this period, the iReceptor Gateway was unable to send email. The following services were affected:
Mar 22, 2024
Service outage: 2024-03-21 - The iReceptor Gateway is currently unable to send email. The following services are currently not working:
Mar 12, 2024
Fifth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 32 Million annotated T-cell receptors from Gomez-Tourino et al "T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes" is now available
Note: 2024-03-11, 10:00 to 22:30 UTC - One of iReceptor Public Archive repositories (ipa2.ireceptor.org) was down and queries during this time did not include data from this repository.
Mar 11, 2024
Fifth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 32 Million annotated T-cell receptors from Gomez-Tourino et al "T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes" is now available
Note: 2024-03-10, 10:00 UTC - One of iReceptor Public Archive repositories is down and has been taken offline in the iReceptor Gateway. Queries will not include this repository until the repository is back up.
Feb 26, 2024
Fifth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 32 Million annotated T-cell receptors from Gomez-Tourino et al "T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes" is now available
Note: 2024-02-26, 10:45 Pacific - Analysis jobs are once again available
Feb 20, 2024
Analysis jobs unavailable - Feb 22, 08:00 - Feb 25, 23:00 Our compute provider the Digital Research Alliance of Canada has a scheduled outage for the compute resource we utilize.
Feb 07, 2024
Fifth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 32 Million annotated T-cell receptors from Gomez-Tourino et al "T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes" is now available
Feb 02, 2024
New Gateway workflows!!! We are pleased to announce the release of iReceptor Gateway v4.1, with new Clone and Cell workflows as well as improved Analysis Job stability with an upgrade to Tapis v3.
2024-02-02, 09:00 Pacific: VDJServer is back online.
Jan 30, 2024
New Gateway workflows!!! We are pleased to announce the release of iReceptor Gateway v4.1, with new Clone and Cell workflows as well as improved Analysis Job stability with an upgrade to Tapis v3.
2024-01-30 - 09:45 Pacific: VDJServer, one of the AIRR Data Commons repositories, is temporarily unavailable, gateway queries will generate errors until the repository is back on line
Jan 26, 2024
New Gateway workflows!!! We are pleased to announce the release of iReceptor Gateway v4.1, with new Clone and Cell workflows as well as improved Analysis Job stability with an upgrade to Tapis v3.
Jan 24, 2024
Maintenance completed 2024-01-24 14:30: The iReceptor Gateway scheduled downtime from from 10:00 Jan 24 to 17:00 Jan 25 Pacific Time has been completed. Let us know if you see any problems.
Fourth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. Annotated T-cell receptors and subject HLA from Anderson et al. "Human islet T cells are highly reactive to preproinsulin in type 1 diabetes" is now available
Jan 16, 2024
Downtime: The iReceptor Gateway will be down from 10:00 Jan 24 to 17:00 Jan 25 Pacific Time for upgrades and maintenance. Apologies for the inconvenience.
Fourth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. Annotated T-cell receptors and subject HLA from Anderson et al. "Human islet T cells are highly reactive to preproinsulin in type 1 diabetes" is now available
Dec 07, 2023
Fourth T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. Annotated T-cell receptors and subject HLA from Anderson et al. "Human islet T cells are highly reactive to preproinsulin in type 1 diabetes" is now available
Dec 02, 2023
2023-08-16: Third Single Cell data set available in the AIRR Data Commons and through the iReceptor Gateway! Single Cell and GEX data from Minervina et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells now available for search, analysis, and download.
Nov 20, 2023
Note: The iReceptor Gateway was down from 02:24 - 08:22 Nov 20 Pacific due to a large number of downloads filling local disk. The problem has been resolved, apologies for the inconvenience.
2023-08-16: Third Single Cell data set available in the AIRR Data Commons and through the iReceptor Gateway! Single Cell and GEX data from Minervina et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells now available for search, analysis, and download.
Nov 08, 2023
2023-08-16: Third Single Cell data set available in the AIRR Data Commons and through the iReceptor Gateway! Single Cell and GEX data from Minervina et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells now available for search, analysis, and download.
Nov 02, 2023
2023-08-16: Third Single Cell data set available in the AIRR Data Commons and through the iReceptor Gateway! Single Cell and GEX data from Minervina et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells now available for search, analysis, and download.
Note: 2023-11-02 2023-11-03: Network outage resolved ,see Digital Research Alliance of Canada is experiencing an outage. Analysis Jobs are back online.
Nov 01, 2023
2023-08-16: Third Single Cell data set available in the AIRR Data Commons and through the iReceptor Gateway! Single Cell and GEX data from Minervina et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells now available for search, analysis, and download.
Oct 14, 2023
2023-08-16: Third Single Cell data set available in the AIRR Data Commons and through the iReceptor Gateway! Single Cell and GEX data from Minervina et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells now available for search, analysis, and download.
IPA2 and IPA4 were temporarily unavailable between Oct 13, 05:00 UTC and Oct 14, 16:00, data from these repositories was not available during this time. All repositories are back on line.
Aug 16, 2023
Third Single Cell data set available in the AIRR Data Commons and through the iReceptor Gateway! Single Cell and GEX data from Minervina et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells now available for search, analysis, and download.
Aug 07, 2023
VDJServer data unavailable - 2023-08-07 17:45 - 19:00 UTC. VDJServer was unavailable during this period and was either not responding or disabled on the Gateway. VDJServer is once again available.
Aug 04, 2023
VDJServer data unavailable - 2023-08-01 07:30 - 2023-08-02 12:00 Pacific time. Data from VDJServer was not available during this time due to a temporary outage
Aug 01, 2023
VDJServer data unavailable - 2023-08-01 07:30 Pacific time. VDJServer has been temporarily disabled on the iReceptor Gateway.
Jul 06, 2023
IPA1 back up! IPA1 was down from 2023-07-06 12:00 - 12:15 Pacific due to technical difficulties and the data from IPA1 was not available for search during this outage
Jun 27, 2023
iReceptor Analysis Apps are once again running. Our compute provider the Digital Research Alliance of Canada had a downtime for maintenance from June 23 - June 27. Analyses are back up and running.
IPA3 is back up! One of the IPA servers (IPA3) was down from 2023-06-14 10:00 to 2023-06-22 14:00 due to technical difficulties. During this time the data from IPA3 was not available for search
Jun 22, 2023
iReceptor Analysis Apps not available June 23 - June 27. Our compute provider the Digital Research Alliance of Canada has a scheduled downtime for the compute resource we use for analysis. Analysis will be disabled during this outage.
IPA3 is back up! One of the IPA servers (IPA3) was down from 2023-06-14 10:00 to 2023-06-22 14:00 due to technical difficulties. During this time the data from IPA3 was not available for search
Jun 14, 2023
IPA3 down - 2023-06-14 10:00 Pacific One of the IPA servers (IPA3) is currently down due to technical difficulties. IPA3 is disabled on the iReceptor Gateway and the data from IPA3 is not available for search
Jun 05, 2023
We are happy to announce a second Single Cell AIRRseq study available in the AIRR Data Commons. Single Cell and GEX data from Wen et al. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing added to the already existing AIRRseq study.
May 16, 2023
A second T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 6.9M annotated TCRs/BCRs from Seay et al "Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes"
Remember: Help us help you by filling out the iReceptor Survey
May 03, 2023
IPA4 is back up - 2023-05-03 14:15 Pacific One of the IPA servers (IPA4) was down from 2023-05-03 08:00 - 14:15 due to technical difficulties. Data from IPA4 was unavailable during this time.
May 03, 2023
IPA4 down - 2023-05-03 08:00 Pacific One of the IPA servers (IPA4) is currently down due to technical difficulties. IPA4 is disabled on the iReceptor Gateway and the data from IPA4 is not available for search
Apr 04, 2023
A second T1D study has been added to the AIRR Data Commons, searchable through the iReceptor Gateway. 6.9M annotated TCRs/BCRs from Seay et al "Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes"
Remember: Help us help you by filling out the iReceptor Survey
Mar 30, 2023
Help us help you by filling out the iReceptor Survey
T1D repository down - 2023-03-28 21:00 - 2023-03-30 12:00 - The T1D repository was down and data was not available during this time.
Mar 29, 2023
Help us help you by filling out the iReceptor Survey
T1D repository down - 2023-03-28 21:00 We are experiencing a technical problem, will note here when the problem is resolved.
Mar 28, 2023
Help us help you by filling out the iReceptor Survey
VDJServer data unavailable - 2023-03-26 04:00 to 2023-03-28 08:50 Pacific time. VDJServer was down and/or disabled on the iReceptor Gateway during this time.
Mar 26, 2023
Help us help you by filling out the iReceptor Survey
VDJServer data unavailable - 2023-03-26 04:00 Pacific time. VDJServer is currently down and is disabled on the iReceptor Gateway.
Mar 02, 2023
Help us help you by filling out the iReceptor Survey
Reminder: iReceptor v4.0 is here. This includes new Single Cell and analysis capabilities and the addition of the first single cell study in the ADC, Yost, et al. "Clonal replacement of tumor-specific T cells following PD-1 blockade"
Jan 09, 2023
New T1D repository added!
Pleased to announce a new T1D specific repository, including 62M annotated sequences (including HLA typing) from Mitchell et al. Temporal development of T cell receptor repertoires during childhood in health and disease
Note: Don't forget to check out the new iReceptor v4.0 features.
Dec 24, 2022
iReceptor v4.0 is here, including new Single Cell and analysis capabilities and the addition of the first single cell study in the ADC, Yost, et al. "Clonal replacement of tumor-specific T cells following PD-1 blockade" (118K annotated sequences, 30K clones, and 66K cells )
NOTE: Service resumed, Analysis Jobs are once again enabled!
Dec 21, 2022
iReceptor v4.0 is here, including new Single Cell and analysis capabilities and the addition of the first single cell study in the ADC, Yost, et al. "Clonal replacement of tumor-specific T cells following PD-1 blockade" (118K annotated sequences, 30K clones, and 66K cells )
NOTE: Analysis jobs temporarily disabled due to outage on service provider.
Dec 17, 2022
iReceptor v4.0 is here!
We are proud to announce the release of iReceptor v4.0, implementing the AIRR v1.4 specification, including new Single Cell and analysis capabilities. We are also excited to announce the first single cell study in the ADC, with 118K annotated sequences, 30K clones, and 66K cells added from Yost, et al. "Clonal replacement of tumor-specific T cells following PD-1 blockade"
NOTE: 2022-12-17, 12:20 PST - IPA6 is back online.
Dec 17, 2022
iReceptor v4.0 is here!
We are proud to announce the release of iReceptor v4.0, implementing the AIRR v1.4 specification, including new Single Cell and analysis capabilities. We are also excited to announce the first single cell study in the ADC, with 118K annotated sequences, 30K clones, and 66K cells added from Yost, et al. "Clonal replacement of tumor-specific T cells following PD-1 blockade"
NOTE: IPA6 is down for maintenance, no single-cell data is currently available.
Dec 07, 2022
iReceptor v4.0 is here!
We are proud to announce the release of iReceptor v4.0, implementing the AIRR v1.4 specification, including new Single Cell and analysis capabilities. We are also excited to announce the first single cell study in the ADC, with 118K annotated sequences, 30K clones, and 66K cells added from Yost, et al. "Clonal replacement of tumor-specific T cells following PD-1 blockade"
Dec 04, 2022
Dec 7, 2022 - 07:00 - 17:00 Pacific - iReceptor Gateway out of service
In preparation for the iReceptor v4.0 release iReceptor services will be unavailable during the above times. Apologies for the inconvenience.
Nov 18, 2022
Nov 18, 2022 - 11:30 PST - COVID19-3/4 back on line
Note: Nov 21 planned outage for iReceptor Gateway postponed to a later date.
Nov 17, 2022
Nov 17, 2022 - 09:00 - 17:00 Pacific - COVID19-3 and COVID19-4 out of service.
Nov 21, 2022 - 07:00 - 17:00 Pacific - iReceptor Gateway out of service
In preparation for the iReceptor v4.0 release iReceptor services will be unavailable during the above times. Apologies for the inconvenience.
Oct 24, 2022
Eighth AIRR Data Commons repository added (Roche/KCL/iReceptor)
Pleased to announce an eighth international repository, including 11.2M annotated sequences from Joseph et al. Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19. The data are now available through the iReceptor Gateway!
Note: IPA 5 back on line as of 2022-10-24 09:25 PST
Oct 21, 2022
Oct 21, 2022 - IPA5 ADC repository not available
The Simon Fraser University IPA5 repository has been disabled due to a technical problem. Data from this repository is currently not queried in any searches.
Oct 16, 2022
Eighth AIRR Data Commons repository added (Roche/KCL/iReceptor)
Pleased to announce an eighth international repository, including 11.2M annotated sequences from Joseph et al. Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19. The data are now available through the iReceptor Gateway!
Oct 07, 2022
iReceptor Gateway unavailable Oct 16, 06:00 - 08:00 Pacific time
Due to networking maintenance from our service provider the iReceptor Gateway and the iReceptor repositories (IPA, COVID19, VDJBase, Roche) will be unavailable until the maintenance is completed.
Aug 11, 2022
Eighth AIRR Data Commons repository added (Roche/KCL/iReceptor)
Pleased to announce an eighth international repository, including 11.2M annotated sequences from Joseph et al. Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19. The data are now available through the iReceptor Gateway!
Jul 16, 2022
VDJServer unavailable 2022-07-16, 07:00 UTC to 2022-07-17 09:30 UTC
The VDJServer repository was unavailable from 2022-07-16, 07:00 UTC to 2022-07-17 09:30 UTC. Any queries issued by the iReceptor Gateway would not have searched VDJServer during this outage. VDJServer is back on line.
Jun 22, 2022
VDJServer is back
The VDJServer repository is available again, after the scheduled maintenance on June 21, 2022.
Jun 20, 2022
VDJServer unavailable on Tuesday
The VDJServer repository will be unavailable on June 21, 2022 because of maintenance.
Jun 13, 2022
2022-06-13, 08:00 - 2022-06-14, 03:00 UTC - IPA5 ADC repository not available
The Simon Fraser University IPA5 repository was down due to a technical problem. IPA5 was disabled and data from this repository would not have been queried in any searches during this downtime.
May 12, 2022
2022-05-12,10:40 Pacific - Muenster ADC repository back on line
The University of Meunster repository in Germany was temporarily unavailable from 2022-05-12, 00:00-10:40 Pacific. It is now back on line. The NICD repository is still down. Any searches performed using the iReceptor Gateway during this time would not have returned results from these repositories.
May 12, 2022
2022-05-12 - 00:00 Pacific - Muenster ADC repository not available
The University of Meunster repository in Germany is temporarily unavailable. The NICD repository is still down as well. Any searches performed using the iReceptor Gateway will not search these repositories until they are back on line.
Apr 29, 2022
2022-04-29 - 09:15 Pacific - NICD (South Africa) repository temporarily unavailable
The NICD repository in South Africa is temporarily unavailable, any searches performed using the iReceptor Gateway will not search this repository until it is back on line.
Mar 16, 2022
Seventh AIRR Data Commons repository added (University of Meunster - Germany)
Pleased to announce a seventh international repository, including 3.6M annotated sequences from Schwab et al. "CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing" are now available through the iReceptor Gateway!
Feb 28, 2022
Sixth AIRR Data Commons repository added (NICD - South Africa)
Pleased to announce a sixth international repository, including 38M annotated sequences from Scheepers et al. "Antibody Isotype Switching as a Mechanism to Counter HIV Neutralization Escape" searchable through the iReceptor Gateway!
Feb 25, 2022
NEW FEATURE - Junction/CDR3 searches linked to IEDB!
User queries for Junction/CDR3 in the AIRR Data Commons are complemented with an additional search to IEDB to look for known antigen or epitope specificity. Organism found on IEDB with specificity are listed and the user is given a link to IEDB to find out more.
Check it out!
Jan 24, 2022
New study exploring Lipid Nanoparticle mRNA vaccines in mice
3.1M annotated sequences from Alameh et al. Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses are now available through the iReceptor Gateway.
Jan 16, 2022
4th COVID-19 vaccine AIRR-seq data set available!!!
406K annotated sequences from Schmitz et al. A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants are now available through the iReceptor Gateway.
Note: ADC repository sciReptor was down from (19:50 UTC 2022-01-04 to 24:00 UTC 2022-01-12). All systems are back on line.
Jan 04, 2022
4th COVID-19 vaccine AIRR-seq data set available!!!
406K annotated sequences from Schmitz et al. A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants are now available through the iReceptor Gateway.
ADC repository sciReptor is down temporarily (19:50 UTC 2022-01-04), we expect it to be back online shortly.
Dec 16, 2021
4th COVID-19 vaccine AIRR-seq data set available!!!
406K annotated sequences from Schmitz et al. A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants are now available through the iReceptor Gateway.
VDJServer is back - due to a networking problem between TACC and Compute Canada VDJServer was unavailable from 2021-12-13 17:15 to 2021-12-16 12:00 (PST) - apologies for the inconvenience.
Dec 13, 2021
4th COVID-19 vaccine AIRR-seq data set available!!!
406K annotated sequences from Schmitz et al. A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants are now available through the iReceptor Gateway.
2021-12-13 17:15 PST: VDJServer is offline due to a networking problem between TACC and Compute Canada - apologies for the inconvenience.
Dec 13, 2021
4th COVID-19 vaccine AIRR-seq data set available!!!
406K annotated sequences from Schmitz et al. A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants are now available through the iReceptor Gateway.
Dec 03, 2021
4th COVID-19 vaccine AIRR-seq data set available!!!
406K annotated sequences from Schmitz et al. A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants are now available through the iReceptor Gateway.
Note: VDJServer is back online. It was offline from Nov 29, 11:30 PST to Dec 2, 14:00 PST.
Nov 29, 2021
4th COVID-19 vaccine AIRR-seq data set available!!!
406K annotated sequences from Schmitz et al. A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants are now available through the iReceptor Gateway.
Note: VDJServer was taken offline for a data and hardware upgrade as of Nov 29, 11:30 PST. We expect it to be back by Dec 3. All other repositories in the AIRR Data Commons remain on line.
Oct 25, 2021
4th COVID-19 vaccine AIRR-seq data set available!!!
406K annotated sequences from Schmitz et al. A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants are now available through the iReceptor Gateway.
Note: The iReceptor Gateway and the IPA and COVID-19 repositories were down from 2021-10-24 22:20 to 2021-10-25 08:30 PST due to an outage on our service provider.
Sep 30, 2021
3rd COVID-19 vaccine AIRR-seq data set available!!!
9.1M annotated sequences from Goel et al. mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern are now available through the iReceptor Gateway.
Sep 20, 2021
3rd COVID-19 vaccine AIRR-seq data set available!!!
9.1M annotated sequences from Goel et al. mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern are now available through the iReceptor Gateway.
2021-09-14: VDJServer was down 08:00 - 18:00.Sep 14, 2021
3rd COVID-19 vaccine AIRR-seq data set available!!!
9.1M annotated sequences from Goel et al. mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern are now available through the iReceptor Gateway.
2021-09-14: VDJServer is down for maintenance, we expect it back on line around 11:00 Central timeSep 13, 2021
3rd COVID-19 vaccine AIRR-seq data set available!!!
9.1M annotated sequences from Goel et al. mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern are now available through the iReceptor Gateway.
Sep 08, 2021
Addition of 5th AIRR Data Commons repository from DKFZ!
We are proud to announce the 5th repository in the AIRR Data Commons, brought to you by DKFZ in Germany and iReceptor Plus! 3.3K annotated sequences from Lorenzo et al. ALDH4A1 is an atherosclerosis auto-antigen targeted by protective antibodies are now available through the iReceptor Gateway.
Aug 31, 2021
2nd COVID-19 vaccine AIRR-seq data set available!!!
41K annotated sequences from Turner et al. SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses are now available through the iReceptor Gateway.
Note: Aug 30, 07:00 - 19:30 Pacific - One of the COVID-19 repositories (part of the Adaptive data set) was down for maintenance, all repositories now back to normal.
Aug 30, 2021
2nd COVID-19 vaccine AIRR-seq data set available!!!
41K annotated sequences from Turner et al. SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses are now available through the iReceptor Gateway.
Note: Aug 30, 07:00 Pacific - One of the COVID-19 repositories (part of the Adaptive data set) and VDJBase are down for maintenance, we expect them back by the end of the dayJul 21, 2021
2nd COVID-19 vaccine AIRR-seq data set available!!!
41K annotated sequences from Turner et al. SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses are now available through the iReceptor Gateway.
Jul 21, 2021
VDJServer down for maintenanceVDJServer maintenance is finished. VDJServer was unavailable from Jul 15 - Aug 4.
Jul 15, 2021
VDJServer down for maintenance IPA4 is back...VDJServer will be down for maintenance Jul 15 and is disabled on the Gateway, we expect it back around Jul 19.
One of the IPA repositories was temporarily down from July 15, 3:00 AM to 10:00 AM Pacific time. All data from the IPA is now back online.
May 18, 2021
1st COVID-19 vaccine AIRR-seq data set available!!!
4.4M annotated sequences from Goel et al. Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination are now available through the iReceptor Gateway.
May 17, 2021
2021-05-18: iReceptor Gateway authentication unavailableOur authentication provider is down for maintenance from Tuesday, May 18th from 8 AM to 5PM CST. Authentication to the iReceptor Gateway will be unavailable for all or part of this time.
ADC repositories will not be affected by this outage, but searching through the iReceptor Gateway will not be possible.
May 15, 2021
Recent updates!2021-05-15: VDJServer is back online!
2021-04-22: New Data: From Sokal et al. Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.
Statistics: Check out our new Stats analysis
May 11, 2021
VDJServer down for maintenance - May 13VDJServer will be down for maintenance May 13. It will be disabled on the Gateway 07:00 Pacific time. Check here for information on when it is back on line.
Update: 2021-05-14 - VDJServer is still down, stay tuned...
Apr 26, 2021
New Data and New Statistics!New Data: 2021-04-22 - New study from Sokal et al. Maturation and persistence of the anti-SARS-CoV-2 memory B cell response added.
Statistics: Check out our new Stats analysis
Apr 11, 2021
New Data and New Statistics!Statistics: Check out our new Stats analysis capability
New Data: New repertoire and new subject data from Shomuradova et al. added. See data provenance for details.
Mar 25, 2021
iReceptor Gateway back online2021-03-25 - 14:28 to 16:17 Pacific time: We experienced a short outage on the iReceptor Gateway due to a technical issue. All repositories and the Gateway are back on line! We apologize for the inconvenience.
Feb 16, 2021
Gateway adds Repertoire Statistics capabilityWe are excited to announce a powerful new Repertoire Statistics capability on the iReceptor Gateway, enabling users to interactively explore VDJ gene usage statistics as well Junction/CDR3 length frequencies. Please log in and visit the Repertoire page or see the iReceptor news announcement on the iReceptor web site for more details.
Feb 10, 2021
13th COVID-19 study and 4th AIRR Data Commons repository available
212K annotated sequences from Mor et. al. Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent Donors are now available through the iReceptor Gateway. In addition we are pleased to announce our 4th AIRR Data Commons repository in collaboration with our colleagues from VDJBase at Bar Ilan University is now online.
Feb 08, 2021
2021-02-08, 09:50 - 15:00 Pacific: VDJServer temporarily off line
Data from VDJServer was temporarily unavailable during the above period. Sorry for the inconvenience.
Feb 04, 2021
2021-02-03, 16:44-17:42 Pacific: covid19-3.ireceptor.org down temporarily
Data from covid19-3 (a subset of the Adaptive ImmuneRace data set) was temporarily unavailable during this time, sorry for the inconvenience.
Jan 31, 2021
2020-01-30: Network issue resolved - VDJServer data available
The networking error between the iReceptor Gateway and VDJServer has been resolved, all data from VDJServer is available for searching. VDJServer data was unavailable through the iReceptor Gateway from 2021-01-29 09:30 to 2021-01-30 17:30 Pacific time. Sorry for any inconveniences.
Jan 29, 2021
2020-01-29: Network issue - VDJServer off line on iReceptor Gateway
We are experiencing a networking issue somewhere between the iReceptor Gateway and VDJServer. We are investigating the issue. Although VDJServer is still up, queries from the iReceptor Gateway to VDJServer are not working. All iReceptor repositories are still on line.
Nov 18, 2020
12th COVID-19 study available
125K annotated sequences from Wen et. al. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing are now available through the iReceptor Gateway.
Nov 12, 2020
New feature: Extended Filters!
The iReceptor Gateway has recently been expanded so that you can choose to filter on any of the AIRR Minimal Standard fields. Previously the Gateway limited users to searching on a fixed set of common fields. Let us know what you think at support@ireceptor.org.
Nov 02, 2020
iReceptor IPA and AIRR COVID-19 Nov 2 Maintenance complete
The iReceptor Public Archive repository and AIRR COVID-19 repositories were offline for maintenance from 11:00 - 11:59 AM Pacific time Nov 2, 2020. All services are back on line.
Oct 30, 2020
iReceptor IPA and AIRR COVID-19 repositories offline for maintenance - Nov 2 11:00 AM - 11:59 AM Pacific
The iReceptor Public Archive repository and AIRR COVID-19 repository will be offline from 11:00 - 11:59 AM Pacific time Nov 2, 2020. The iReceptor Gateway will continue to be online but the 2.5B rearrangements from these repositories will not be available during this time.
Oct 13, 2020
VDJServer online, new COVID-19 data available
700M annotated sequences added to VDJServer including two COVID-19 data sets, one from Nolan et. al. and one from Montague et al. are now available through the iReceptor Gateway.
Sep 18, 2020
VDJServer unavailable
VDJServer is temporarily unavailable while upgrades/changes are being made. The 650M sequence annotations from VDJServer are not searchable at this time. We will update this space when VDJServer is back.
Sep 11, 2020
10th COVID-19 study available
542 M annotated sequences from Nolan et. al. A large-scale database of T-cell receptor beta (TCRβ) sequences and binding associations from natural and synthetic exposure to SARS-CoV-2 are now available through the iReceptor Gateway.
Sep 04, 2020
Aug 31: 9th COVID-19 study available
12 M annotated sequences from Kuri-Cervantes et. al Comprehensive mapping of immune perturbations associated with severe COVID-19 are now available through the iReceptor Gateway.
Sep 03, 2020
Gateway download problem - RESOLVED
This issue has been resolved, downloads are working once more. We are currently experiencing problems with data downloads on the iReceptor Gateway. If you are waiting for a download, we apologize for the inconvenience. We will publish a note here when the problem is resolved.
Aug 31, 2020
9th COVID-19 study available
12 M annotated sequences from Kuri-Cervantes et. al Comprehensive mapping of immune perturbations associated with severe COVID-19 are now available through the iReceptor Gateway.
Aug 25, 2020
iReceptor Public Archive (IPA) repository issue
From 18:00 August 24 to 08:00 August 25 one of the IPA servers was down. During this time 452 Million sequence annotations from Zvyagin et al "Tracking T-cell immune reconstitution after TCRαβ/CD19-depleted hematopoietic cells transplantation in children" were unavailable. All services are now back on line.
Aug 24, 2020
Network outage Aug 25 07:00 - 07:30 PST
iReceptor's infrastructure provider, Compute Canada, has a scheduled network outage on Tuesday August 25 between 7:00-7:30 PDT/10:00-10:30 EDT. The outage is expected to be less than 2 minutes, but could be up to 20 minutes. All iReceptor services may be impacted by this outage.
Aug 04, 2020
8th COVID-19 study available
3.4 M annotated sequences from Kim et. al Stereotypic Neutralizing VH Clonotypes Against SARS-CoV-2 RBD in COVID-19 Patients and the Healthy Population are now available through the iReceptor Gateway.
Jul 11, 2020
6th and 7th COVID-19/SARS-CoV2 studies available
7 studies, including 3.9 M annotated sequences from SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors and 13 K annotated mouse sequences from A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection are now available.
Jul 09, 2020
Five COVID-19 studies available
180 M annotated sequences from five COVID-19 studies are available for exploration and download through the iReceptor Gateway. For more information about these studies see the iReceptor COVID-19 information page.
Jul 09, 2020
VDJServer back on line
The VDJServer AIRR Data Commons repository is back on line and all data are available through the iReceptor Gateway.
Jul 07, 2020
VDJServer repository down for maintenance
The VDJServer AIRR Data Commons repository will be down for maintenance from July 7 for several days. As a result, queries to VDJServer and its > 500M sequence rearrangements will not be available during this time. We will make an announcement here when VDJServer is back on line.
Jul 02, 2020
Fifth COVID-19 study available
13.5 M annotated sequences from Schultheiß et al. "Next Generation Sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease" now available through the iReceptor Gateway.
Jun 29, 2020
Fourth COVID-19 study available
66.9 M annotated sequences from Liao et al. "Single-cell Landscape of Bronchoalveolar Immune Cells in Patients With COVID-19" now available through the iReceptor Gateway.
Jun 22, 2020
Third COVID-19 study available
3.7 M annotated sequences from Galson et al. "Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures" now available.
Jun 15, 2020
Second COVID-19 study available
87 million annotated sequences from the pre-press paper Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection from Minervina, et al. have been added.
Jun 04, 2020
iReceptor upgraded to v3.0 - COVID-19 data available! The iReceptor v3.0 upgrade implements the recently released AIRR v1.3 standard. All repositories in the iReceptor Public Archive have been upgraded.We are also pleased to announce the addition of the AIRR COVID-19 repository, with our first AIRR-seq COVID-19 data set.Jun 04, 2020
Downtime noticeThe iReceptor Gateway will be down for maintenance and a platform upgrade on June 4, 2020 from 11:00 - 15:00 Pacific time. Sorry for the inconvenience...
Mar 27, 2020
AIRR Community calls for public sharing of COVID-19 dataThe AIRR Community recently made a public call for the sharing of AIRR-seq data. In their call they state "... the AIRR-C hereby calls upon its members, and the wider research community, to share experiences, resources, samples, and data as openly and freely as possible, and to work within their respective systems to break down barriers to achieve this goal, subject to the overarching directives of respect, privacy, and protection for patients and all people. We are in this together."
Mar 18, 2020
iReceptor Gateway and Repositories down 08:50 - 10:45 Pacific, Mar 18, 2020
Our service provider Compute Canada had a network outage that made the iReceptor services unavailable during this time. All service are now back on line.
Feb 06, 2020
IPA maintenance Feb 6, 2020 completed.
A maintenance outage was required for one of the iReceptor Public Archive repositories from 7:30 AM - 8:30 AM Pacific Time, Feb 6, 2020. During this period 400M rearrangements were not available. All services are now back online.
Feb 06, 2020
IPA maintenance required - Feb 6, 2020.
A maintenance outage was required for one of the iReceptor Public Archive repositories from 7:30 AM - 8:30 AM Pacific Time, Feb 6, 2020. During this period 400M rearrangements were not available. Searches on other IPA and external repositories were not affected.
Dec 20, 2019
Scheduled Maintenance Jan 8, 2020.
On Wednesday, January 8, external network access to the iReceptor service provider (Compute Canada) will be interrupted for up to 30 minutes during a 1-hour network maintenance window from 7:00 pm to 8:00 pm (PST) / 10:00 pm to 11:00 pm (EST). There will be no access to the iReceptor Gateway and the iReceptor Public Archive repositories during this outage.
Nov 25, 2019
Scheduled Maintenance Dec 4, 2019.
On Wednesday, December 4, external network access to the iReceptor service provider (Compute Canada) will be interrupted for at least 1 hour during a 3-hour network maintenance window from 7:00 to 10:00 pm (PST) / 10:00 pm to 1:00 am (EST). There will be no access to the iReceptor Gateway and the iReceptor Public Archive repositories during this outage.
Nov 19, 2019
Update Nov 20, 2019: The issue has been resolved and the sequences are available again.
Nov 19, 2019 - 389 million sequences are unavailable
389 million sequences are currently unavailable because of a technical problem with the iReceptor Public Archive. We expect the situation to be resolved over the next few days.
Oct 02, 2019
2019-09-03: iReceptor reaches 2 Billion annotated sequences
463M annotated sequences added from two new studies: Vergani, et al. (37M) "Novel Method for High-Throughput Full-Length IGHV-D-J Sequencing of the Immune Repertoire from Bulk B-Cells with Single-Cell Resolution" and Pogorelyy, et al. (426M) "Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins" were added to the iReceptor Public Archive
Sep 13, 2019
Scheduled maintenance: Sep 25, 7:00 - 10:00 pm (PDT)External network access to our service provider, Compute Canada, will be interrupted for at least 1 hour during a 3-hour network maintenance window from 7:00 - 10:00 pm (PDT) / 10:00 pm - 1:00 am (EDT). The iReceptor Gateway and the iReceptor Public Archive repositories will be unavailable at this time.
Sep 04, 2019
2018-03-09: iReceptor reaches 2 Billion annotated sequences
463M annotated sequences added from two new studies: Vergani, et al. (37M) "Novel Method for High-Throughput Full-Length IGHV-D-J Sequencing of the Immune Repertoire from Bulk B-Cells with Single-Cell Resolution" and Pogorelyy, et al. (426M) "Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins" were added to the iReceptor Public Archive
Aug 09, 2019
Scheduled IPA maintenance complete
2019-08-03 13:30 PDT: Maintenance has been completed, all services and repositories are back on line!
Aug 08, 2019
Scheduled IPA maintenance: August 8, 10:00-12:00 PDT
We are making an important code update which will make some of the repositories unavailable during this time period. Searches performed during this time will not search the entire AIRR Data Commons.
Update: Maintenance is taking slightly longer than expected, we expect to be back by 13:00 PDT
Jul 29, 2019
181M annotated sequences back on line
Internal query optimizations that were causing issues (reported 2019-07-03) have been fixed. 181M annotated sequences from the studies that were taken offline on 2019-07-03 are now back online. For more information see the iReceptor Public Archive Data Provenance page
Jul 03, 2019
181M annotated sequences temporarily removed
An error in an internal optimization mechanism on the iReceptor repository has been discovered that resulted in incorrect V/D/J gene searches on two studies from 2019-06-21 to 2019-07-03. The problem will be fixed and the data will be back in production soon. For more information see the iReceptor Public Archive Data Provenance page
Jun 26, 2019
June 26 maintenance finished
The Tapis (AGAVE) authentication service maintenance is finished, the iReceptor Gateway is back on line.
Jun 25, 2019
Scheduled outage on June 26
This Wednesday, from 6am to 3pm Pacific Time, our authentication service provider Tapis (formerly Agave), will undergo maintenance. It won't be possible to log in to the iReceptor Gateway during that time.
Jun 21, 2019
154M annotated sequences added
Data from two new studies: Sims, et al. "Diversity and divergence of the glioma-infiltrating T-cell receptor repertoire." and Jia, et al. "Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer."
Jun 21, 2019
27M annotated sequences added
27M annotated sequences added from Stern, et al. "B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes" added to the iReceptor Public Archive.
Jun 19, 2019
IPA maintenance: June 19, 15:20-17:00 PDT
On Wednesday, June 19, maintenance was required on several of the iReceptor Public Archive repositories. Two of the four repositories were unavailable during this time period. Any searches performed during this time would have not have searched the entire AIRR Data Commons.
Jun 14, 2019
IPA maintenance: June 14, 15:00-17:00 PDT
On Thursday, June 14, maintenance was required on several of the iReceptor Public Archive repositories. Two of the four repositories were down for 30 minutes each during this time period. Any searches performed during this time would have not have searched the entire AIRR Data Commons.
Jun 03, 2019
Scheduled outage: June 13, 20:00-21:00 PDT
On Thursday, June 13, external network access to our service provider, Compute Canada, will be interrupted for up to 30 minutes during a 1-hour network maintenance window from 8:00 p.m. to 9:00 p.m. (PDT). During this time the iReceptor Gateway and the IPA repository will be unavailable.
May 06, 2019
AIRR Community Meeting - May 10 to 15
The iReceptor Team is looking forward to seeing colleagues at the AIRR Community meeting in Genoa to talk about sharing AIRR-seq data!
Apr 30, 2019
April 30, 2019 - iReceptor Public Archive back online
The technical problems we experienced from Apr 22 - Apr 30 have been resolved. Our 1.3B sequence annotations are back!
Apr 26, 2019
Apr 22, 2019 - iReceptor Public Archive offline
We are currently experiencing technical issues with the file system from our service provider. All repositories are currently disabled until this issue has been fixed.
We expect to be fully back on line Apr 30, PM Pacific time.
Mar 22, 2019
March 22, 2019 - 200M annotated sequences added
Data from three new studies of tumour-infiltrating lymphocytes in oesophageal squamous cell carcinoma, glioblastoma, and primary liver carcinoma have been added. More information on these studies is available on the iReceptor website.
Jan 24, 2019
2019-01-24: 452M annotated sequences added
Data from Zvyagin et. al. "Tracking T-cell immune reconstitution after TCRαβ/CD19-depleted hematopoietic cells transplantation in children" added to the iReceptor Public Archive. Over 1 Billion annotated sequences now available!Nov 28, 2018
2018-11-27: Data download limit removed
The data download limit of 500,000 sequence annotations has now been removed. Users are able to download large data sets, with the current limit now a 24 hour time limit! Note that large downloads may take a long time, with download speeds ranging from 3M to 90M sequence annotations/hour.
Oct 17, 2018
2018-10-17: 312M annotated sequences added
Data from Wang et. al. "The Different T-cell Receptor Repertoires in Breast Cancer Tumors, Draining Lymph Nodes, and Adjacent Tissues" added to the iReceptor Public Archive.
Jul 06, 2018
2018-07-12: iReceptor version 2.0 is now available
Both the iReceptor Public Archive (IPA) (Simon Fraser University/Compute Canada) and VDJServer (University of Texas Southwestern Medical School) repositories are available.
Jun 01, 2018
2018-06-01: iReceptor version 2.0 is now available.
Only a single study is accessible at this time, but we expect the iReceptor Public Archive (Victoria) and VDJServer (Texas) repositories to support the v2.0 Gateway at the end of June.