What's New

Nov 18, 2020

12th COVID-19 study available

125K annotated sequences from Wen et. al. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing are now available through the iReceptor Gateway.

Nov 12, 2020

New feature: Extended Filters!

The iReceptor Gateway has recently been expanded so that you can choose to filter on any of the AIRR Minimal Standard fields. Previously the Gateway limited users to searching on a fixed set of common fields. Let us know what you think at support@ireceptor.org.

Nov 02, 2020

iReceptor IPA and AIRR COVID-19 Nov 2 Maintenance complete

The iReceptor Public Archive repository and AIRR COVID-19 repositories were offline for maintenance from 11:00 - 11:59 AM Pacific time Nov 2, 2020. All services are back on line.

Oct 30, 2020

iReceptor IPA and AIRR COVID-19 repositories offline for maintenance - Nov 2 11:00 AM - 11:59 AM Pacific

The iReceptor Public Archive repository and AIRR COVID-19 repository will be offline from 11:00 - 11:59 AM Pacific time Nov 2, 2020. The iReceptor Gateway will continue to be online but the 2.5B rearrangements from these repositories will not be available during this time.

Oct 13, 2020

VDJServer online, new COVID-19 data available

700M annotated sequences added to VDJServer including two COVID-19 data sets, one from Nolan et. al. and one from Montague et al. are now available through the iReceptor Gateway.

Sep 18, 2020

VDJServer unavailable

VDJServer is temporarily unavailable while upgrades/changes are being made. The 650M sequence annotations from VDJServer are not searchable at this time. We will update this space when VDJServer is back.

Sep 11, 2020

10th COVID-19 study available

542 M annotated sequences from Nolan et. al. A large-scale database of T-cell receptor beta (TCRβ) sequences and binding associations from natural and synthetic exposure to SARS-CoV-2 are now available through the iReceptor Gateway.

Sep 04, 2020

Aug 31: 9th COVID-19 study available

12 M annotated sequences from Kuri-Cervantes et. al Comprehensive mapping of immune perturbations associated with severe COVID-19 are now available through the iReceptor Gateway.

Sep 03, 2020

Gateway download problem - RESOLVED

This issue has been resolved, downloads are working once more. We are currently experiencing problems with data downloads on the iReceptor Gateway. If you are waiting for a download, we apologize for the inconvenience. We will publish a note here when the problem is resolved.

Aug 31, 2020

9th COVID-19 study available

12 M annotated sequences from Kuri-Cervantes et. al Comprehensive mapping of immune perturbations associated with severe COVID-19 are now available through the iReceptor Gateway.

Aug 25, 2020

iReceptor Public Archive (IPA) repository issue

From 18:00 August 24 to 08:00 August 25 one of the IPA servers was down. During this time 452 Million sequence annotations from Zvyagin et al "Tracking T-cell immune reconstitution after TCRαβ/CD19-depleted hematopoietic cells transplantation in children" were unavailable. All services are now back on line.

Aug 24, 2020

Network outage Aug 25 07:00 - 07:30 PST

iReceptor's infrastructure provider, Compute Canada, has a scheduled network outage on Tuesday August 25 between 7:00-7:30 PDT/10:00-10:30 EDT. The outage is expected to be less than 2 minutes, but could be up to 20 minutes. All iReceptor services may be impacted by this outage.

Aug 04, 2020

8th COVID-19 study available

3.4 M annotated sequences from Kim et. al Stereotypic Neutralizing VH Clonotypes Against SARS-CoV-2 RBD in COVID-19 Patients and the Healthy Population are now available through the iReceptor Gateway.

Jul 11, 2020

6th and 7th COVID-19/SARS-CoV2 studies available

7 studies, including 3.9 M annotated sequences from SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors and 13 K annotated mouse sequences from A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection are now available.

Jul 09, 2020

Five COVID-19 studies available

180 M annotated sequences from five COVID-19 studies are available for exploration and download through the iReceptor Gateway. For more information about these studies see the iReceptor COVID-19 information page.

Jul 09, 2020

VDJServer back on line

The VDJServer AIRR Data Commons repository is back on line and all data are available through the iReceptor Gateway.

Jul 07, 2020

VDJServer repository down for maintenance

The VDJServer AIRR Data Commons repository will be down for maintenance from July 7 for several days. As a result, queries to VDJServer and its > 500M sequence rearrangements will not be available during this time. We will make an announcement here when VDJServer is back on line.

Jul 02, 2020

Fifth COVID-19 study available

13.5 M annotated sequences from Schultheiß et al. "Next Generation Sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease" now available through the iReceptor Gateway.

Jun 29, 2020

Fourth COVID-19 study available

66.9 M annotated sequences from Liao et al. "Single-cell Landscape of Bronchoalveolar Immune Cells in Patients With COVID-19" now available through the iReceptor Gateway.

Jun 22, 2020

Third COVID-19 study available

3.7 M annotated sequences from Galson et al. "Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures" now available.

Jun 15, 2020

Second COVID-19 study available

87 million annotated sequences from the pre-press paper Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection from Minervina, et al. have been added.

Jun 04, 2020

iReceptor upgraded to v3.0 - COVID-19 data available! The iReceptor v3.0 upgrade implements the recently released AIRR v1.3 standard. All repositories in the iReceptor Public Archive have been upgraded.We are also pleased to announce the addition of the AIRR COVID-19 repository, with our first AIRR-seq COVID-19 data set.

Jun 04, 2020

Downtime notice

The iReceptor Gateway will be down for maintenance and a platform upgrade on June 4, 2020 from 11:00 - 15:00 Pacific time. Sorry for the inconvenience...

Mar 27, 2020

AIRR Community calls for public sharing of COVID-19 data

The AIRR Community recently made a public call for the sharing of AIRR-seq data. In their call they state "... the AIRR-C hereby calls upon its members, and the wider research community, to share experiences, resources, samples, and data as openly and freely as possible, and to work within their respective systems to break down barriers to achieve this goal, subject to the overarching directives of respect, privacy, and protection for patients and all people. We are in this together."

Mar 18, 2020

iReceptor Gateway and Repositories down 08:50 - 10:45 Pacific, Mar 18, 2020

Our service provider Compute Canada had a network outage that made the iReceptor services unavailable during this time. All service are now back on line.

Feb 06, 2020

IPA maintenance Feb 6, 2020 completed.

A maintenance outage was required for one of the iReceptor Public Archive repositories from 7:30 AM - 8:30 AM Pacific Time, Feb 6, 2020. During this period 400M rearrangements were not available. All services are now back online.

Feb 06, 2020

IPA maintenance required - Feb 6, 2020.

A maintenance outage was required for one of the iReceptor Public Archive repositories from 7:30 AM - 8:30 AM Pacific Time, Feb 6, 2020. During this period 400M rearrangements were not available. Searches on other IPA and external repositories were not affected.

Dec 20, 2019

Scheduled Maintenance Jan 8, 2020.

On Wednesday, January 8, external network access to the iReceptor service provider (Compute Canada) will be interrupted for up to 30 minutes during a 1-hour network maintenance window from 7:00 pm to 8:00 pm (PST) / 10:00 pm to 11:00 pm (EST). There will be no access to the iReceptor Gateway and the iReceptor Public Archive repositories during this outage.

Nov 25, 2019

Scheduled Maintenance Dec 4, 2019.

On Wednesday, December 4, external network access to the iReceptor service provider (Compute Canada) will be interrupted for at least 1 hour during a 3-hour network maintenance window from 7:00 to 10:00 pm (PST) / 10:00 pm to 1:00 am (EST). There will be no access to the iReceptor Gateway and the iReceptor Public Archive repositories during this outage.

Nov 19, 2019

Update Nov 20, 2019: The issue has been resolved and the sequences are available again.

Nov 19, 2019 - 389 million sequences are unavailable

389 million sequences are currently unavailable because of a technical problem with the iReceptor Public Archive. We expect the situation to be resolved over the next few days.

Oct 02, 2019

2019-09-03: iReceptor reaches 2 Billion annotated sequences

463M annotated sequences added from two new studies: Vergani, et al. (37M) "Novel Method for High-Throughput Full-Length IGHV-D-J Sequencing of the Immune Repertoire from Bulk B-Cells with Single-Cell Resolution" and Pogorelyy, et al. (426M) "Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins" were added to the iReceptor Public Archive

Sep 13, 2019

Scheduled maintenance: Sep 25, 7:00 - 10:00 pm (PDT)

External network access to our service provider, Compute Canada, will be interrupted for at least 1 hour during a 3-hour network maintenance window from 7:00 - 10:00 pm (PDT) / 10:00 pm - 1:00 am (EDT). The iReceptor Gateway and the iReceptor Public Archive repositories will be unavailable at this time.

Sep 04, 2019

2018-03-09: iReceptor reaches 2 Billion annotated sequences

463M annotated sequences added from two new studies: Vergani, et al. (37M) "Novel Method for High-Throughput Full-Length IGHV-D-J Sequencing of the Immune Repertoire from Bulk B-Cells with Single-Cell Resolution" and Pogorelyy, et al. (426M) "Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins" were added to the iReceptor Public Archive

Aug 09, 2019

Scheduled IPA maintenance complete

2019-08-03 13:30 PDT: Maintenance has been completed, all services and repositories are back on line!

Aug 08, 2019

Scheduled IPA maintenance: August 8, 10:00-12:00 PDT

We are making an important code update which will make some of the repositories unavailable during this time period. Searches performed during this time will not search the entire AIRR Data Commons.

Update: Maintenance is taking slightly longer than expected, we expect to be back by 13:00 PDT

Jul 29, 2019

181M annotated sequences back on line

Internal query optimizations that were causing issues (reported 2019-07-03) have been fixed. 181M annotated sequences from the studies that were taken offline on 2019-07-03 are now back online. For more information see the iReceptor Public Archive Data Provenance page

Jul 03, 2019

181M annotated sequences temporarily removed

An error in an internal optimization mechanism on the iReceptor repository has been discovered that resulted in incorrect V/D/J gene searches on two studies from 2019-06-21 to 2019-07-03. The problem will be fixed and the data will be back in production soon. For more information see the iReceptor Public Archive Data Provenance page

Jun 26, 2019

June 26 maintenance finished

The Tapis (AGAVE) authentication service maintenance is finished, the iReceptor Gateway is back on line.

Jun 25, 2019

Scheduled outage on June 26

This Wednesday, from 6am to 3pm Pacific Time, our authentication service provider Tapis (formerly Agave), will undergo maintenance. It won't be possible to log in to the iReceptor Gateway during that time.

Jun 21, 2019

27M annotated sequences added

27M annotated sequences added from Stern, et al. "B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes" added to the iReceptor Public Archive.

Jun 19, 2019

IPA maintenance: June 19, 15:20-17:00 PDT

On Wednesday, June 19, maintenance was required on several of the iReceptor Public Archive repositories. Two of the four repositories were unavailable during this time period. Any searches performed during this time would have not have searched the entire AIRR Data Commons.

Jun 14, 2019

IPA maintenance: June 14, 15:00-17:00 PDT

On Thursday, June 14, maintenance was required on several of the iReceptor Public Archive repositories. Two of the four repositories were down for 30 minutes each during this time period. Any searches performed during this time would have not have searched the entire AIRR Data Commons.

Jun 03, 2019

Scheduled outage: June 13, 20:00-21:00 PDT

On Thursday, June 13, external network access to our service provider, Compute Canada, will be interrupted for up to 30 minutes during a 1-hour network maintenance window from 8:00 p.m. to 9:00 p.m. (PDT). During this time the iReceptor Gateway and the IPA repository will be unavailable.

May 06, 2019

AIRR Community Meeting - May 10 to 15

The iReceptor Team is looking forward to seeing colleagues at the AIRR Community meeting in Genoa to talk about sharing AIRR-seq data!

Apr 30, 2019

April 30, 2019 - iReceptor Public Archive back online

The technical problems we experienced from Apr 22 - Apr 30 have been resolved. Our 1.3B sequence annotations are back!

Apr 26, 2019

Apr 22, 2019 - iReceptor Public Archive offline

We are currently experiencing technical issues with the file system from our service provider. All repositories are currently disabled until this issue has been fixed.

We expect to be fully back on line Apr 30, PM Pacific time.

Mar 22, 2019

March 22, 2019 - 200M annotated sequences added

Data from three new studies of tumour-infiltrating lymphocytes in oesophageal squamous cell carcinoma, glioblastoma, and primary liver carcinoma have been added. More information on these studies is available on the iReceptor website.

Jan 24, 2019

2019-01-24: 452M annotated sequences added

Data from Zvyagin et. al. "Tracking T-cell immune reconstitution after TCRαβ/CD19-depleted hematopoietic cells transplantation in children" added to the iReceptor Public Archive. Over 1 Billion annotated sequences now available!

Nov 28, 2018

2018-11-27: Data download limit removed

The data download limit of 500,000 sequence annotations has now been removed. Users are able to download large data sets, with the current limit now a 24 hour time limit! Note that large downloads may take a long time, with download speeds ranging from 3M to 90M sequence annotations/hour.

Oct 17, 2018

2018-10-17: 312M annotated sequences added

Data from Wang et. al. "The Different T-cell Receptor Repertoires in Breast Cancer Tumors, Draining Lymph Nodes, and Adjacent Tissues" added to the iReceptor Public Archive.

Jul 06, 2018

2018-07-12: iReceptor version 2.0 is now available

Both the iReceptor Public Archive (IPA) (Simon Fraser University/Compute Canada) and VDJServer (University of Texas Southwestern Medical School) repositories are available.

Jun 01, 2018

2018-06-01: iReceptor version 2.0 is now available.

Only a single study is accessible at this time, but we expect the iReceptor Public Archive (Victoria) and VDJServer (Texas) repositories to support the v2.0 Gateway at the end of June.

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