What's New
2025-10-06: 325M new TCR sequences now available in the AIRR Data Commons through the iReceptor Gateway. The iReceptor and iReceptor Genomic Services teams are pleased to announce a large, new T1D study of over 325M TCR sequence from a cohort of 805 subjects from Karakas et al. "T-Cell Receptor Sequences Targeting Beta-Cell Proteins Are Present in Blood across the Stages of Type 1 Diabetes Development".
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A science gateway that enables the discovery, analysis, and download of AIRR-seq data (antibody/B-cell and T-cell receptor repertoires) from the 10 remote repositories in the AIRR Data Commons (ADC). Search for disease data (e.g. cancer, autoimmunity, infections) and healthy controls.
5.6 billion annotated sequences (bulk/single-cell) from 11267 repertoires, 96 studies, 10 repositories
10 remote repositories, 79 research labs, 96 studies
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AIRR COVID-19
765.8 million sequences
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Lab:
Adaptive Biotechnologies
543.4 million sequences
- Study: Nolan et al., COVID-19-Adaptive: A large-scale database of T-cel‥ 111.7 million sequences
- Study: Nolan et al., COVID-19-BWNW: A large-scale database of T-cell re‥ 33.2 million sequences
- Study: Nolan et al., COVID-19-DLS: A large-scale database of T-cell rec‥ 155.4 million sequences
- Study: Nolan et al., COVID-19-HUniv12Oct: A large-scale database of T-c‥ 84.2 million sequences
- Study: Nolan et al., COVID-19-IRST/AUSL: A large-scale database of T-ce‥ 29 million sequences
- Study: Nolan et al., COVID-19-ISB: A large-scale database of T-cell rec‥ 74.3 million sequences
- Study: Nolan et al., COVID-19-NIH/NIAID: A large-scale database of T-ce‥ 55.4 million sequences
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Lab:
Alchemab Therapeutics Ltd
3.7 million sequences
- Study: Galson et al., Deep sequencing of B cell receptor repertoires fr‥ 3.7 million sequences
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Lab:
Binder Lab, Department of Internal Medicine IV, Oncology/Hematol‥
15.1 million sequences
- Study: Schultheiß et al., Next Generation Sequencing of T and B cell re‥ 15.1 million sequences
-
Lab:
Boyd Lab, Department of Pathology, Stanford University
8.9 million sequences
- Study: Nielsen et al., B cell clonal expansion and convergent antibody‥ 8.9 million sequences
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Lab:
Cancer Research Institute, Seoul National University College of‥
3.4 million sequences
- Study: Kim et al., Stereotypic Neutralizing VH Clonotypes Against SARS-‥ 3.4 million sequences
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Lab:
Efimov Lab, National Research Centre for Hematology, Moscow, Rus‥
7.7 million sequences
- Study: Shomuradova et al., SARS-CoV-2 epitopes are recognized by a publ‥ 7.7 million sequences
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Lab:
Ellebedy Lab, Department of Pathology and Immunology, Washington‥
54 thousand sequences
- Study: Alsoussi et al., A Potently Neutralizing Antibody Protects Mice‥ 13 thousand sequences
- Study: Turner et al., SARS-CoV-2 mRNA vaccines induce persistent human‥ 41 thousand sequences
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Lab:
Ellebedy Lab, Washington University School of Medicine
406 thousand sequences
- Study: Schmitz et al., A vaccine-induced public antibody protects again‥ 406 thousand sequences
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Lab:
Institute for Hepatology, National Clinical Research Center for‥
66.9 million sequences
- Study: Liao et al., Single-cell landscape of bronchoalveolar immune cel‥ 66.9 million sequences
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Lab:
Mora Lab, Laboratoire de physique de l’École normale supérieure‥
87.1 million sequences
- Study: Minervina et al., Longitudinal high-throughput TCR repertoire pr‥ 87.1 million sequences
-
Lab:
National Center for Liver Cancer, Second Military Medical Univer‥
104 thousand sequences
- Study: Wen et al., Immune cell profiling of COVID-19 patients in the re‥ 104 thousand sequences
-
Lab:
Pardi Lab, Department of Medicine, University of Pennsylvania
3 million sequences
- Study: Alameh et al., Lipid nanoparticles enhance the efficacy of mRNA‥ 3 million sequences
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Lab:
Perelman School of Medicine, University of Pennsylvania
11.9 million sequences
- Study: Kuri-Cervantes et al., Comprehensive mapping of immune perturbat‥ 11.9 million sequences
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Lab:
Reynaud Lab, Institut Necker Enfants Malades (INEM), INSERM
104 thousand sequences
- Study: Sokal et al., Maturation and persistence of the anti-SARS-CoV-2‥ 104 thousand sequences
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Lab:
Thomas Lab, Department of Immunology, St. Jude Children’s Resear‥
23 thousand sequences
- Study: Minervina et al., SARS-CoV-2 antigen exposure history shapes phe‥ 23 thousand sequences
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Lab:
Wherry Lab, Perelman School of Medicine, University of Pennsylva‥
13.5 million sequences
- Study: Goel et al., Distinct antibody and memory B cell responses in SA‥ 4.4 million sequences
- Study: Goel et al., mRNA Vaccination Induces Durable Immune Memory to S‥ 9.1 million sequences
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Lab:
Adaptive Biotechnologies
543.4 million sequences
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Greiff Lab
9.9 million sequences
-
Lab:
Alchemab Therapeutics Ltd, London, United Kingdom
4.8 million sequences
- Study: Lê Quý, et al. Benchmarking and integrating human B-cell recepto‥ 9.9 million sequences
-
Lab:
Computational and System Immunology lab, Department of Immunolog‥
5 million sequences
- Study: Lê Quý, et al. Benchmarking and integrating human B-cell recepto‥ 9.9 million sequences
-
Lab:
Alchemab Therapeutics Ltd, London, United Kingdom
4.8 million sequences
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HPAP
1.1 million sequences
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Lab:
Luning Prak Lab, Perelman School of Medicine, University of Penn‥
1.1 million sequences
- Study: Human Pancreas Analysis Program T1D bulk TRB data 1.1 million sequences
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Lab:
Luning Prak Lab, Perelman School of Medicine, University of Penn‥
1.1 million sequences
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iReceptor Public Archive
1.8 billion sequences
-
Lab:
Bagnara Lab, Department of Experimental Medicine, University of‥
38.8 million sequences
- Study: Vergani et al., Novel Method for High-Throughput Full-Length IGH‥ 38.8 million sequences
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Lab:
Bo Zhu Lab, Institute of Cancer, Xinqiao Hospital, Third Militar‥
9 million sequences
- Study: Jia et al., Local mutational diversity drives intratumoral immun‥ 9 million sequences
-
Lab:
Chang Lab, Center for Personal Dynamic Regulomes, Stanford Unive‥
118 thousand sequences
- Study: Yost et al., Clonal replacement of tumor-specific T cells follow‥ 118 thousand sequences
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Lab:
Chudakov Lab, Shemyakin-Ovchinnikov Institute of Bioorganic Chem‥
452.3 million sequences
- Study: Zvyagin et al., Tracking T-cell immune reconstruction after TCR/‥ 452.3 million sequences
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Lab:
Collins Lab, School of Biotechnology and Biomolecular Sciences,‥
1.1 million sequences
- Study: Collins et al., The Mouse Antibody Heavy Chain Repertoire Is Ger‥ 1.1 million sequences
-
Lab:
Department of Immunology and Microbiology, University of Colorad‥
49.9 million sequences
- Study: Munson et al., Identification of shared TCR sequences from T cel‥ 49.9 million sequences
-
Lab:
Department of Neurological Surgery, Columbia University Medical‥
144.9 million sequences
- Study: Sims et al., Diversity and divergence of the glioma-infiltrating‥ 144.9 million sequences
-
Lab:
Fire Lab, Department of Pathology, Stanford University
1 million sequences
- Study: Boyd et al., Measurement and Clinical Monitoring of Human Lympho‥ 1 million sequences
-
Lab:
Institute of Molecular and Genomic Medicine, National Health Res‥
61.1 million sequences
- Study: Chang et al., Network Signatures of IgG Immune Repertoires in He‥ 61.1 million sequences
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Lab:
Kellam Lab, Wellcome Trust Sanger Institute
1 million sequences
- Study: Bashford-Rogers et al., Network properties derived from deep seq‥ 1 million sequences
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Lab:
Key Laboratory of Carcinogenesis and Translational Research (Min‥
82.4 million sequences
- Study: Chen et al., T cell Beta chain repertoire analysis reveals intra‥ 82.4 million sequences
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Lab:
Lebedev Lab, Department of Genomics of Adaptive Immunity, Shemya‥
426.4 million sequences
- Study: Pogorelyy et al., Precise tracking of vaccine-responding T cell‥ 426.4 million sequences
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Lab:
Martinez-Barnetche Lab, Departamento de Inmunología; Centro de I‥
713 thousand sequences
- Study: Valdés-Alemán et al., Hybridization-based antibody cDNA recovery‥ 713 thousand sequences
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Lab:
Mehr Lab, The Mina and Everard Goodman Faculty of Life Sciences,‥
27 thousand sequences
- Study: Michaeli et al., Immunoglobulin gene repertoire diversification‥ 27 thousand sequences
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Lab:
National Cancer Center/Cancer Hospital, Chinese Academy of Medic‥
29.2 million sequences
- Study: Feng et al., Heterogeneity of tumor-infiltrating lymphocytes asc‥ 29.2 million sequences
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Lab:
Sanz Lab, Department of Medicine, Division of Rheumatology, Emor‥
27.9 million sequences
- Study: Tipton et al., Diversity, cellular origin and autoreactivity of‥ 27.9 million sequences
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Lab:
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian‥
55 million sequences
- Study: Putintseva et al., Mother and child T cell receptor repertoires:‥ 55 million sequences
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Lab:
Sollid Lab, Centre for Immune Regulation and Department of Immun‥
32.6 million sequences
- Study: Snir et al., Stereotyped antibody responses target posttranslati‥ 32.6 million sequences
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Lab:
State Key Laboratory of Molecular Oncology, Department of Etiolo‥
95.2 million sequences
- Study: Shi et al., Multi-omics study revealing the complexity and spati‥ 95.2 million sequences
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Lab:
Vaccine Research Center, National Institutes of Health
3.8 million sequences
- Study: Zhou et al., Multi-donor Analysis Reveal Structural Elements, Ge‥ 3.8 million sequences
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Lab:
Vaccine Research Center, National Institutes of Health Intramura‥
3.6 million sequences
- Study: Zhu et al., Mining the antibodyome for HIV-1 neutralizing antibo‥ 3.6 million sequences
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Lab:
von Buedingen Lab, Department of Neurology, University of Califo‥
1.2 million sequences
- Study: Palanichamy et al., Immunoglobulin class-switched B cells provid‥ 1.2 million sequences
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Lab:
Xiao Liu Lab, BGI-Shenzhen
312.1 million sequences
- Study: Wang et al., The Different T-cell Receptor Repertoires in Breast‥ 312.1 million sequences
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Lab:
Bagnara Lab, Department of Experimental Medicine, University of‥
38.8 million sequences
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Roche
17.2 million sequences
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Lab:
Hayday Lab, Peter Gorer Department of Immunobiology, King's Coll‥
17.2 million sequences
- Study: Global patterns of antigen receptor repertoire disruption across‥ 17.2 million sequences
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Lab:
Hayday Lab, Peter Gorer Department of Immunobiology, King's Coll‥
17.2 million sequences
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sciReptor
20 thousand sequences
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Lab:
Div. B Cell Immunology, German Cancer Research Center
3 thousand sequences
- Study: Lorenzo et al., ALDH4A1 is an atherosclerosis auto-antigen targe‥ 3 thousand sequences
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Lab:
MPRG Molucular Immunology, MPI Infection Biology
17 thousand sequences
- Study: Busse et al., Single-cell based high-throughput sequencing of fu‥ 532 sequences
- Study: omega 16 thousand sequences
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Lab:
Div. B Cell Immunology, German Cancer Research Center
3 thousand sequences
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T1D
442.9 million sequences
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Lab:
Barbara Davis Center for Diabetes
387.5 million sequences
- Study: Anderson et al., Human islet T cells are highly reactive to prep‥ 6 thousand sequences
- Study: Karakus et al., 29-OR: T-Cell Receptor Sequences Targeting Beta-‥ 325.3 million sequences
- Study: Mitchell et al., Temporal development of T cell receptor reperto‥ 62.1 million sequences
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Lab:
Benaroya Research Institute
9.6 million sequences
- Study: Culina et al., Islet-reactive CD8+ T cell frequencies in the pan‥ 9.6 million sequences
-
Lab:
Immunobiology Dpt. King's College London
34.4 million sequences
- Study: Eugster et al., Physiological and pathogenic T cell autoreactivi‥ 688 sequences
- Study: Gomez-Tourino et al., T cell receptor β-chains display abnormal‥ 34.4 million sequences
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Lab:
University of Florida Diabetes Institute
11 million sequences
- Study: Seay et al., Tissue distribution and clonal diversity of the T a‥ 11 million sequences
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Lab:
University of Massachusetts Chan Medical School
195 thousand sequences
- Study: Kent et al., Islet-derived, in vitro polyclonally expanded T cel‥ 195 thousand sequences
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Lab:
Barbara Davis Center for Diabetes
387.5 million sequences
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University of Münster
3.6 million sequences
-
Lab:
Institut für Translationale Neurologie
3.6 million sequences
- Study: CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated b‥ 3.6 million sequences
-
Lab:
Institut für Translationale Neurologie
3.6 million sequences
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VDJbase
212 thousand sequences
-
Lab:
Freund Lab, Faculty of Medicine, Tel Aviv University
212 thousand sequences
- Study: Mor et al., Multi-clonal SARS-CoV-2 neutralization by antibodies‥ 212 thousand sequences
-
Lab:
Freund Lab, Faculty of Medicine, Tel Aviv University
212 thousand sequences
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VDJServer
2.5 billion sequences
-
Lab:
Adaptive Biotechnologies
308.2 million sequences
- Study: A large-scale database of T-cell receptor beta (TCRb) sequences‥ 308.2 million sequences
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Lab:
Ali H. Ellebedy
12 thousand sequences
- Study: A Potently Neutralizing Antibody Protects Mice against SARS-CoV-‥ 12 thousand sequences
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Lab:
Anne Eugster
130.8 million sequences
- Study: T cell receptor repertoires after adoptive transfer of expanded‥ 130.8 million sequences
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Lab:
Armita Nourmohammad and Chris Ka Pun Mok
18.9 million sequences
- Study: Dynamics of B-cell repertoires and emergence of cross-reactive r‥ 18.9 million sequences
-
Lab:
Dana Pe’er
106 thousand sequences
- Study: Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor‥ 106 thousand sequences
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Lab:
Dennis R. Burton
405.4 million sequences
- Study: Uniqueness, commonality and exceptional diversity in the baselin‥ 405.4 million sequences
-
Lab:
George Georgiou
101.1 million sequences
- Study: In-depth determination and analysis of the human paired heavy- a‥ 45.7 million sequences
- Study: Large-scale sequence and structural comparisons of human naive a‥ 55.4 million sequences
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Lab:
Harlan Robins
245.2 million sequences
- Study: A public database of memory and naive B-cell receptor sequences 46.6 million sequences
- Study: Dynamics of the Cytotoxic T Cell Response to a Model of Acute Vi‥ 6.9 million sequences
- Study: Immunosequencing identifies signatures of cytomegalovirus exposu‥ 191.6 million sequences
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Lab:
Ignacio Sanz
15 thousand sequences
- Study: Extrafollicular B cell responses correlate with neutralizing ant‥ 15 thousand sequences
-
Lab:
Ivelin S. Georgiev
14 thousand sequences
- Study: High-Throughput Mapping of B Cell Receptor Sequences to Antigen‥ 14 thousand sequences
-
Lab:
James E. Crowe Jr
1.1 billion sequences
- Study: High Frequency of Shared Clonotypes in Human T Cell Receptor Rep‥ 1.1 billion sequences
-
Lab:
Jia Zhu
37 thousand sequences
- Study: Distinct populations of antigen-specific tissue-resident CD8+ T‥ 37 thousand sequences
-
Lab:
Jianxin Shi and Mahboobeh Safaeian
3.4 million sequences
- Study: T cell receptor repertoire among women who cleared and failed to‥ 3.4 million sequences
-
Lab:
Jörg J Goronzy
56.9 million sequences
- Study: Determinants governing T cell receptor α/β-chain pairing in repe‥ 56.9 million sequences
-
Lab:
Lawrence Shapiro
6.6 million sequences
- Study: Maturation and Diversity of the VRC01-Antibody Lineage over 15 Y‥ 6.6 million sequences
-
Lab:
Lindsay Cowell
94 thousand sequences
- Study: Biophysicochemical Motifs in T cell Receptor Sequences as a Pote‥ 94 thousand sequences
-
Lab:
Lindsay G. Cowell
236 thousand sequences
- Study: T cell Receptor Repertoires Acquired via Routine Pap Testing May‥ 236 thousand sequences
-
Lab:
Lisong Shen
87 thousand sequences
- Study: Immune suppressive landscape in the human esophageal squamous ce‥ 87 thousand sequences
-
Lab:
Luis Graca
6.3 million sequences
- Study: T follicular helper and T follicular regulatory cells have diffe‥ 6.3 million sequences
-
Lab:
Mark M. Davis
1.7 million sequences
- Study: Individual heritable differences result in unique cell lymphocyt‥ 1.7 million sequences
-
Lab:
Michael R. Wilson
438 thousand sequences
- Study: A pathogenic and clonally expanded B cell transcriptome in activ‥ 438 thousand sequences
-
Lab:
Pandurangan Vijayanand
367 thousand sequences
- Study: Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4 +‥ 367 thousand sequences
-
Lab:
Rafi Ahmed
183 thousand sequences
- Study: Functional HPV-specific PD-1+ stem-like CD8 T cells in head and‥ 183 thousand sequences
-
Lab:
Raquibul Hannan
782 thousand sequences
- Study: Outcome and Immune Correlates of a Phase II Trial of High-Dose I‥ 782 thousand sequences
-
Lab:
Sai T. Reddy
125.4 million sequences
- Study: Antibody repertoire RNA-seq throughout key stages of mouse B-cel‥ 125.4 million sequences
-
Lab:
Steven H. Kleinstein
17.3 million sequences
- Study: A Model of Somatic Hypermutation Targeting in Mice Based on High‥ 1.1 million sequences
- Study: B cells populating the multiple sclerosis brain mature in the dr‥ 6.7 million sequences
- Study: Hierarchical Clustering Can Identify B Cell Clones With High Con‥ 9.4 million sequences
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Lab:
UNKNOWN
- Study: Low avidity T cell responses to SARS-CoV-2 in unexposed individu‥ 125 thousand sequences
-
Lab:
Zheng Zhang
11 thousand sequences
- Study: Single-cell landscape of bronchoalveolar immune cells in patient‥ 11 thousand sequences
-
Lab:
Adaptive Biotechnologies
308.2 million sequences
See all AIRR Data Commons repositories queried by the iReceptor Gateway
67 thousand clones aggregated from 64 repertoires, 2 studies, 2 repositories
10 remote repositories, 79 research labs, 96 studies
-
AIRR COVID-19
37 thousand clones
-
Lab:
National Center for Liver Cancer, Second Military Medical Univer‥
37 thousand clones
- Study: Wen et al., Immune cell profiling of COVID-19 patients in the re‥ 37 thousand clones
-
Lab:
National Center for Liver Cancer, Second Military Medical Univer‥
37 thousand clones
-
iReceptor Public Archive
30 thousand clones
-
Lab:
Chang Lab, Center for Personal Dynamic Regulomes, Stanford Unive‥
30 thousand clones
- Study: Yost et al., Clonal replacement of tumor-specific T cells follow‥ 30 thousand clones
-
Lab:
Chang Lab, Center for Personal Dynamic Regulomes, Stanford Unive‥
30 thousand clones
530 thousand sorted, single B/T cells with paired receptors, gene expression, and cell phenotype from 175 repertoires, 5 studies, 4 repositories
10 remote repositories, 79 research labs, 96 studies
-
AIRR COVID-19
67 thousand cells
-
Lab:
National Center for Liver Cancer, Second Military Medical Univer‥
54 thousand cells
- Study: Wen et al., Immune cell profiling of COVID-19 patients in the re‥ 54 thousand cells
-
Lab:
Thomas Lab, Department of Immunology, St. Jude Children’s Resear‥
12 thousand cells
- Study: Minervina et al., SARS-CoV-2 antigen exposure history shapes phe‥ 12 thousand cells
-
Lab:
National Center for Liver Cancer, Second Military Medical Univer‥
54 thousand cells
-
Greiff Lab
396 thousand cells
-
Lab:
Alchemab Therapeutics Ltd, London, United Kingdom
122 thousand cells
- Study: Lê Quý, et al. Benchmarking and integrating human B-cell recepto‥ 396 thousand cells
-
Lab:
Computational and System Immunology lab, Department of Immunolog‥
274 thousand cells
- Study: Lê Quý, et al. Benchmarking and integrating human B-cell recepto‥ 396 thousand cells
-
Lab:
Alchemab Therapeutics Ltd, London, United Kingdom
122 thousand cells
-
iReceptor Public Archive
66 thousand cells
-
Lab:
Chang Lab, Center for Personal Dynamic Regulomes, Stanford Unive‥
66 thousand cells
- Study: Yost et al., Clonal replacement of tumor-specific T cells follow‥ 66 thousand cells
-
Lab:
Chang Lab, Center for Personal Dynamic Regulomes, Stanford Unive‥
66 thousand cells
-
T1D
482 cells
-
Lab:
Immunobiology Dpt. King's College London
482 cells
- Study: Eugster et al., Physiological and pathogenic T cell autoreactivi‥ 482 cells
-
Lab:
Immunobiology Dpt. King's College London
482 cells