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What's New
4th COVID-19 vaccine AIRR-seq data set available!!!
406K annotated sequences from Schmitz et al. A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants are now available through the iReceptor Gateway.
Note: The iReceptor Gateway and the IPA and COVID-19 repositories were down from 2021-10-24 22:20 to 2021-10-25 08:30 PST due to an outage on our service provider.
A science gateway that enables the discovery, analysis and download of AIRR-seq data (antibody/B-cell and T-cell receptor repertoires) from multiple independent repositories (the AIRR Data Commons), including:
Search study metadata and sequence features from 4 billion sequences, 6520 repertoires, and 67 studies across 5 remote repositories.
5 remote repositories, 53 research labs, 67 studies
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AIRR COVID-19
762.7 million sequences
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Lab:
Adaptive Biotechnologies
543.4 million sequences
- Study: Nolan et al., COVID-19-Adaptive: A large-scale database of T-cel‥ 111.7 million sequences
- Study: Nolan et al., COVID-19-BWNW: A large-scale database of T-cell re‥ 33.2 million sequences
- Study: Nolan et al., COVID-19-DLS: A large-scale database of T-cell rec‥ 155.4 million sequences
- Study: Nolan et al., COVID-19-HUniv12Oct: A large-scale database of T-c‥ 84.2 million sequences
- Study: Nolan et al., COVID-19-IRST/AUSL: A large-scale database of T-ce‥ 29 million sequences
- Study: Nolan et al., COVID-19-ISB: A large-scale database of T-cell rec‥ 74.3 million sequences
- Study: Nolan et al., COVID-19-NIH/NIAID: A large-scale database of T-ce‥ 55.4 million sequences
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Lab:
Alchemab Therapeutics Ltd
3.7 million sequences
- Study: Galson et al., Deep sequencing of B cell receptor repertoires fr‥ 3.7 million sequences
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Lab:
Binder Lab, Department of Internal Medicine IV, Oncology/Hematol‥
15.1 million sequences
- Study: Schultheiß et al., Next Generation Sequencing of T and B cell re‥ 15.1 million sequences
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Lab:
Boyd Lab, Department of Pathology, Stanford University
8.9 million sequences
- Study: Nielsen et al., B cell clonal expansion and convergent antibody‥ 8.9 million sequences
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Lab:
Cancer Research Institute, Seoul National University College of‥
3.4 million sequences
- Study: Kim et al., Stereotypic Neutralizing VH Clonotypes Against SARS-‥ 3.4 million sequences
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Lab:
Efimov Lab, National Research Centre for Hematology, Moscow, Rus‥
7.7 million sequences
- Study: Shomuradova et al., SARS-CoV-2 epitopes are recognized by a publ‥ 7.7 million sequences
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Lab:
Ellebedy Lab, Department of Pathology and Immunology, Washington‥
54 thousand sequences
- Study: Alsoussi et al., A Potently Neutralizing Antibody Protects Mice‥ 13 thousand sequences
- Study: Turner et al., SARS-CoV-2 mRNA vaccines induce persistent human‥ 41 thousand sequences
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Lab:
Ellebedy Lab, Washington University School of Medicine
406 thousand sequences
- Study: Schmitz et al., A vaccine-induced public antibody protects again‥ 406 thousand sequences
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Lab:
Institute for Hepatology, National Clinical Research Center for‥
66.9 million sequences
- Study: Liao et al., Single-cell landscape of bronchoalveolar immune cel‥ 66.9 million sequences
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Lab:
Mora Lab, Laboratoire de physique de l’École normale supérieure‥
87.1 million sequences
- Study: Minervina et al., Longitudinal high-throughput TCR repertoire pr‥ 87.1 million sequences
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Lab:
National Center for Liver Cancer, Second Military Medical Univer‥
125 thousand sequences
- Study: Wen et al., Immune cell profiling of COVID-19 patients in the re‥ 125 thousand sequences
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Lab:
Perelman School of Medicine, University of Pennsylvania
11.9 million sequences
- Study: Kuri-Cervantes et al., Comprehensive mapping of immune perturbat‥ 11.9 million sequences
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Lab:
Reynaud Lab, Institut Necker Enfants Malades (INEM), INSERM
104 thousand sequences
- Study: Sokal et al., Maturation and persistence of the anti-SARS-CoV-2‥ 104 thousand sequences
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Lab:
Wherry Lab, Perelman School of Medicine, University of Pennsylva‥
13.5 million sequences
- Study: Goel et al., Distinct antibody and memory B cell responses in SA‥ 4.4 million sequences
- Study: Goel et al., mRNA Vaccination Induces Durable Immune Memory to S‥ 9.1 million sequences
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Lab:
Adaptive Biotechnologies
543.4 million sequences
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iReceptor Public Archive
1.8 billion sequences
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Lab:
Bagnara Lab, Department of Experimental Medicine, University of‥
38.8 million sequences
- Study: Vergani et al., Novel Method for High-Throughput Full-Length IGH‥ 38.8 million sequences
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Lab:
Bo Zhu Lab, Institute of Cancer, Xinqiao Hospital, Third Militar‥
9 million sequences
- Study: Jia et al., Local mutational diversity drives intratumoral immun‥ 9 million sequences
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Lab:
Chudakov Lab, Shemyakin-Ovchinnikov Institute of Bioorganic Chem‥
452.3 million sequences
- Study: Zvyagin et al., Tracking T-cell immune reconstruction after TCR/‥ 452.3 million sequences
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Lab:
Collins Lab, School of Biotechnology and Biomolecular Sciences,‥
1.1 million sequences
- Study: Collins et al., The Mouse Antibody Heavy Chain Repertoire Is Ger‥ 1.1 million sequences
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Lab:
Department of Immunology and Microbiology, University of Colorad‥
49.9 million sequences
- Study: Munson et al., Identification of shared TCR sequences from T cel‥ 49.9 million sequences
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Lab:
Department of Neurological Surgery, Columbia University Medical‥
144.9 million sequences
- Study: Sims et al., Diversity and divergence of the glioma-infiltrating‥ 144.9 million sequences
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Lab:
Fire Lab, Department of Pathology, Stanford University
1 million sequences
- Study: Boyd et al., Measurement and Clinical Monitoring of Human Lympho‥ 1 million sequences
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Lab:
Institute of Molecular and Genomic Medicine, National Health Res‥
61.1 million sequences
- Study: Chang et al., Network Signatures of IgG Immune Repertoires in He‥ 61.1 million sequences
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Lab:
Kellam Lab, Wellcome Trust Sanger Institute
1 million sequences
- Study: Bashford-Rogers et al., Network properties derived from deep seq‥ 1 million sequences
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Lab:
Key Laboratory of Carcinogenesis and Translational Research (Min‥
82.4 million sequences
- Study: Chen et al., T cell Beta chain repertoire analysis reveals intra‥ 82.4 million sequences
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Lab:
Lebedev Lab, Department of Genomics of Adaptive Immunity, Shemya‥
426.4 million sequences
- Study: Pogorelyy et al., Precise tracking of vaccine-responding T cell‥ 426.4 million sequences
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Lab:
Martinez-Barnetche Lab, Departamento de Inmunología; Centro de I‥
713 thousand sequences
- Study: Valdés-Alemán et al., Hybridization-based antibody cDNA recovery‥ 713 thousand sequences
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Lab:
Mehr Lab, The Mina and Everard Goodman Faculty of Life Sciences,‥
27 thousand sequences
- Study: Michaeli et al., Immunoglobulin gene repertoire diversification‥ 27 thousand sequences
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Lab:
National Cancer Center/Cancer Hospital, Chinese Academy of Medic‥
29.2 million sequences
- Study: Feng et al., Heterogeneity of tumor-infiltrating lymphocytes asc‥ 29.2 million sequences
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Lab:
Sanz Lab, Department of Medicine, Division of Rheumatology, Emor‥
27.9 million sequences
- Study: Tipton et al., Diversity, cellular origin and autoreactivity of‥ 27.9 million sequences
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Lab:
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian‥
55 million sequences
- Study: Putintseva et al., Mother and child T cell receptor repertoires:‥ 55 million sequences
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Lab:
Sollid Lab, Centre for Immune Regulation and Department of Immun‥
32.6 million sequences
- Study: Snir et al., Stereotyped antibody responses target posttranslati‥ 32.6 million sequences
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Lab:
State Key Laboratory of Molecular Oncology, Department of Etiolo‥
95.2 million sequences
- Study: Shi et al., Multi-omics study revealing the complexity and spati‥ 95.2 million sequences
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Lab:
Vaccine Research Center, National Institutes of Health
3.8 million sequences
- Study: Zhou et al., Multi-donor Analysis Reveal Structural Elements, Ge‥ 3.8 million sequences
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Lab:
Vaccine Research Center, National Institutes of Health Intramura‥
3.6 million sequences
- Study: Zhu et al., Mining the antibodyome for HIV-1 neutralizing antibo‥ 3.6 million sequences
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Lab:
von Buedingen Lab, Department of Neurology, University of Califo‥
1.2 million sequences
- Study: Palanichamy et al., Immunoglobulin class-switched B cells provid‥ 1.2 million sequences
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Lab:
Xiao Liu Lab, BGI-Shenzhen
312.1 million sequences
- Study: Wang et al., The Different T-cell Receptor Repertoires in Breast‥ 312.1 million sequences
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Lab:
Bagnara Lab, Department of Experimental Medicine, University of‥
38.8 million sequences
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sciReptor
20 thousand sequences
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Lab:
Div. B Cell Immunology, German Cancer Research Center
3 thousand sequences
- Study: Lorenzo et al., ALDH4A1 is an atherosclerosis auto-antigen targe‥ 3 thousand sequences
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Lab:
MPRG Molucular Immunology, MPI Infection Biology
17 thousand sequences
- Study: Busse et al., Single-cell based high-throughput sequencing of fu‥ 532 sequences
- Study: omega 16 thousand sequences
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Lab:
Div. B Cell Immunology, German Cancer Research Center
3 thousand sequences
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VDJbase
212 thousand sequences
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Lab:
Freund Lab, Faculty of Medicine, Tel Aviv University
212 thousand sequences
- Study: Mor et al., Multi-clonal SARS-CoV-2 neutralization by antibodies‥ 212 thousand sequences
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Lab:
Freund Lab, Faculty of Medicine, Tel Aviv University
212 thousand sequences
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VDJServer
1.4 billion sequences
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Lab:
Adaptive Biotechnologies
308.2 million sequences
- Study: A large-scale database of T-cell receptor beta (TCRb) sequences‥ 308.2 million sequences
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Lab:
Anne Eugster
130.8 million sequences
- Study: T cell receptor repertoires after adoptive transfer of expanded‥ 130.8 million sequences
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Lab:
Armita Nourmohammad and Chris Ka Pun Mok
18.9 million sequences
- Study: Dynamics of B-cell repertoires and emergence of cross-reactive r‥ 18.9 million sequences
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Lab:
Dennis R. Burton
405.4 million sequences
- Study: Uniqueness, commonality and exceptional diversity in the baselin‥ 405.4 million sequences
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Lab:
George Georgiou
101.1 million sequences
- Study: In-depth determination and analysis of the human paired heavy- a‥ 45.7 million sequences
- Study: Large-scale sequence and structural comparisons of human naive a‥ 55.4 million sequences
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Lab:
Harlan Robins
245.2 million sequences
- Study: A public database of memory and naive B-cell receptor sequences 46.6 million sequences
- Study: Dynamics of the Cytotoxic T Cell Response to a Model of Acute Vi‥ 6.9 million sequences
- Study: Immunosequencing identifies signatures of cytomegalovirus exposu‥ 191.6 million sequences
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Lab:
Jianxin Shi and Mahboobeh Safaeian
3.4 million sequences
- Study: T cell receptor repertoire among women who cleared and failed to‥ 3.4 million sequences
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Lab:
Jörg J Goronzy
56.9 million sequences
- Study: Determinants governing T cell receptor α/β-chain pairing in repe‥ 56.9 million sequences
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Lab:
Lawrence Shapiro
6.6 million sequences
- Study: Maturation and Diversity of the VRC01-Antibody Lineage over 15 Y‥ 6.6 million sequences
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Lab:
Lindsay Cowell
94 thousand sequences
- Study: Biophysicochemical Motifs in T cell Receptor Sequences as a Pote‥ 94 thousand sequences
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Lab:
Luis Graca
6.3 million sequences
- Study: T follicular helper and T follicular regulatory cells have diffe‥ 6.3 million sequences
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Lab:
Mark M. Davis
1.7 million sequences
- Study: Individual heritable differences result in unique cell lymphocyt‥ 1.7 million sequences
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Lab:
Sai T. Reddy
125.4 million sequences
- Study: Antibody repertoire RNA-seq throughout key stages of mouse B-cel‥ 125.4 million sequences
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Lab:
Steven H. Kleinstein
17.3 million sequences
- Study: A Model of Somatic Hypermutation Targeting in Mice Based on High‥ 1.1 million sequences
- Study: B cells populating the multiple sclerosis brain mature in the dr‥ 6.7 million sequences
- Study: Hierarchical Clustering Can Identify B Cell Clones With High Con‥ 9.4 million sequences
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Lab:
Adaptive Biotechnologies
308.2 million sequences